Carolyn L. Smith
University of Western Ontario
17 Papers
123 Citations
Carolyn L. Smith is an academic researcher from University of Western Ontario. The author has contributed to research in topics: Transcortin & Complementary DNA. The author has an hindex of 15, co-authored 17 publications. Previous affiliations of Carolyn L. Smith include Lawson Health Research Institute.
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Papers
Spatial and temporal distribution of corticosteroid-binding globulin and its messenger ribonucleic acid in embryonic and fetal mice.
TL;DR: The results presented here suggest that temporal and spatial changes in the localization of CBG and its mRNA in the fetus may influence the effects of steroid hormones on developing tissues.
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Interaction between corticosteroid binding globulin and activated leukocytes in vitro
TL;DR: It is suggested that corticosteroid binding globulin interacts with elastase on the surface of activated neutrophils, and may promote glucocorticoid delivery to these cells during inflammation.
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Squirrel monkey corticosteroid-binding globulin: primary structure and comparison with the human protein.
Geoffrey L. Hammond,Carolyn L. Smith,P Lähteenmäki,A Grolla,S Warmels-Rodenhiser,H Hodgert,J T Murai,P K Siiteri +7 more
TL;DR: expression of cDNAs for human and squirrel monkey CBGs in Chinese hamster ovary (CHO) cells and compared the physico-chemical properties of the products with those of the corresponding serum proteins demonstrated that Squirrel monkey CBG is produced by CHO cells as a dimer, and its subunit size heterogeneity is similar to that associated with CBG in serum.
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Corticosteroid binding globulin, testosterone-estradiol binding globulin, and androgen binding protein belong to protein families distinct from steroid receptors
C.W. Bardin,Glen L. Gunsalus,Neal A. Musto,C Y Cheng,J Reventos,Carolyn L. Smith,Underhill Da,Geoffrey L. Hammond +7 more
TL;DR: The cDNA nucleotide sequences and the deduced amino acid sequences of human corticosteroid binding globulin, human testosterone-estradiol binding Globulin, and rat androgen binding protein were determined and it is concluded that the "extracellular steroid binding proteins and steroid receptors do not appear to have descended from a common ancestor".
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Serum distribution of two contraceptive progestins: 3-ketodesogestrel and gestodene.
Geoffrey L. Hammond,Wayne P. Bocchinfuso,M. Orava,Carolyn L. Smith,A. van den Ende,A. Van Enk +5 more
TL;DR: It is concluded that ethinylestradiol-induced increases in serum SHBG levels during treatment with Marvelon or Femovan influenced the distribution and total amount of 3-ketodesogestrel and gestodene in serum, respectively, and that this, combined with the higher affinity of SHBG for Gestodene, results in a greater amount of bioavailable gestodenes compared to 3- ketodesogESTrel, despite the smaller dose of gestodne administered.
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