Carolyn Allen
National Institutes of Health
6 Papers
12 Citations
Carolyn Allen is an academic researcher from National Institutes of Health. The author has contributed to research in topics: RYR1 & Myopathy. The author has an hindex of 4, co-authored 5 publications.
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Papers
Intracellular calcium leak as a therapeutic target for RYR1-related myopathies.
Alexander Kushnir,Joshua J. Todd,Jessica W Witherspoon,Qi Yuan,Steven Reiken,Harvey Lin,Ross H Munce,Benjamin Wajsberg,Zephan Melville,Oliver B. Clarke,Kaylee Wedderburn-Pugh,Anetta Wronska,Muslima S Razaqyar,Irene C Chrismer,Monique O Shelton,Ami Mankodi,Christopher Grunseich,Mark A. Tarnopolsky,Kurenai Tanji,Michio Hirano,Sheila Riazi,Natalia Kraeva,Nicol C. Voermans,Angela Gruber,Carolyn Allen,Katherine G. Meilleur,Andrew R. Marks +26 more
TL;DR: The rationale for a clinical trial testing Rycals in RYR1-RM affected individuals is provided and a predictive tool for investigating the pathogenicity of RYP1 variants of uncertain significance is introduced.
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Correlation of phenotype with genotype and protein structure in RYR1 -related disorders
Joshua J. Todd,Vatsala Sagar,Tokunbor A. Lawal,Carolyn Allen,Muslima S Razaqyar,Monique Shelton,Irene C Chrismer,Xuemin Zhang,Mary M. Cosgrove,Anna Kuo,Ruhi Vasavada,Minal S. Jain,M. Waite,Dinusha Rajapakse,Jessica W Witherspoon,Graeme Wistow,Katherine G. Meilleur +16 more
TL;DR: Variants in the skeletal muscle ryanodine receptor 1 gene (RYR1) result in a spectrum of RYR1-related disorders and are corroborated genotype-phenotype correlations and identified RyR1 regions that may be especially sensitive to structural modification.
Feeding modes, duration, and diarrhea in infancy: Continued evidence of the protective effects of breastfeeding.
Ana F. Diallo,Kelly McGlothen-Bell,Ruth Lucas,Stephen J. Walsh,Carolyn Allen,Wendy A. Henderson,Xiaomei Cong,Jacqueline M. McGrath +7 more
TL;DR: Exclusive breastfeeding for 3 months accompanied by any breastfeeding for 6 months provided the most protective effect against diarrhea, and public health interventions should address disparities in breastfeeding practices and provide support across clinical, workplace and community settings.
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PCR203 The Clinical and Financial Impact of GLP-1 Receptor Agonist and SGLT-2 Inhibitor Use in Type 2 Diabetes Management of Blue Cross and Blue Shield of Louisiana Members
Thomas L Vandergrift,M Liu,Brice Labruzzo Mohundro,Carolyn Allen,Jason Ouyang,B. Vicidomina,Somesh Nigam +6 more
TL;DR: In this paper , the effectiveness of GLP-1 Receptor Agonists and SGLT-2 Inhibitors for lowering HbA1c and reducing health care costs and utilization in members with Type 2 Diabetes was evaluated.
Novel Variants in Individuals with RYR1-Related Congenital Myopathies: Genetic, Laboratory, and Clinical Findings.
Joshua J. Todd,Muslima S Razaqyar,Jessica W Witherspoon,Tokunbor A. Lawal,Ami Mankodi,Irene C Chrismer,Carolyn Allen,Mary D Meyer,Anna Kuo,Monique Shelton,Kim Amburgey,Dmitriy Niyazov,Pierre Fequiere,Carsten G. Bönnemann,James J. Dowling,Katherine G. Meilleur +15 more
TL;DR: This study demonstrates that a genetics-led approach is suitable for the diagnosis of suspected RYR1-RM which can be corroborated through histopathology, muscle MRI and clinical examination.