Caroline Underhill
University of British Columbia
19 Papers
98 Citations
Caroline Underhill is an academic researcher from University of British Columbia. The author has contributed to research in topics: Neutrophil elastase & Biology. The author has an hindex of 14, co-authored 18 publications. Previous affiliations of Caroline Underhill include Family Research Institute & University of Western Ontario.
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Papers
Prenatal SSRI exposure alters neonatal corticosteroid binding globulin, infant cortisol levels, and emerging HPA function.
TL;DR: Prenatal SSRI exposure affects the developing HPA system by altering serum CBG levels in neonates and infant salivary cortisol levels, which influences the development of the hypothalamic-pituitary-adrenal (HPA) system.
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Effects of aggressive encounters on plasma corticosteroid-binding globulin and its ligands in white-crowned sparrows
TL;DR: The hypothesis that aggressive encounters in the late breeding season would not increase total testosterone levels in plasma, but would alter CBG, total corticosterone or total progesterone levels in such a way as to modify the number of available binding sites and therefore occupancy by testosterone is tested.
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Novel corticosteroid-binding globulin variant that lacks steroid binding activity.
Ilias Perogamvros,Caroline Underhill,David Henley,Kristen D. Hadfield,William G. Newman,David W. Ray,Stafford L. Lightman,Geoffrey L. Hammond,Peter J Trainer +8 more
TL;DR: A novel CBG variant that lacks steroid binding activity is described, and it is suggested that this may influence glucocorticoid signaling and contribute to symptoms previously associated with CBG deficiency.
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Interaction between corticosteroid binding globulin and activated leukocytes in vitro
TL;DR: It is suggested that corticosteroid binding globulin interacts with elastase on the surface of activated neutrophils, and may promote glucocorticoid delivery to these cells during inflammation.
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In silico identification of anthropogenic chemicals as ligands of zebrafish sex hormone binding globulin
Nels Thorsteinson,Fuqiang Ban,Osvaldo A. Santos-Filho,Seyed M.H. Tabaei,Solange Miguel-Queralt,Caroline Underhill,Artem Cherkasov,Geoffrey L. Hammond +7 more
TL;DR: The study demonstrates the feasibility of large-scale in silico screening of anthropogenic compounds that may disrupt or highjack functionally important protein:ligand interactions at relatively low cost.
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