Caroline Smith
John Innes Centre
32 Papers
41 Citations
Caroline Smith is an academic researcher from John Innes Centre. The author has contributed to research in topics: Gene & Gene expression. The author has an hindex of 17, co-authored 27 publications. Previous affiliations of Caroline Smith include University of Oxford & University of Tübingen.
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Papers
Reduced cellulose synthesis invokes lignification and defense responses in Arabidopsis thaliana
TL;DR: It is shown that reduced levels of cellulose synthesis, caused by mutations in cellulose synthase genes and in genes affecting cell expansion, activate lignin synthesis and defense responses through jasmonate and ethylene and other signaling pathways.
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Characterisation of a pine MYB that regulates lignification.
Astrid Patzlaff,Stephanie McInnis,Adrian Courtenay,Christine Surman,Lisa J. Newman,Caroline Smith,Michael W. Bevan,Shawn D. Mansfield,Ross W. Whetten,Ronald R. Sederoff,Malcolm M. Campbell +10 more
TL;DR: Electrophoretic mobility shift assays showed that recombinant PtMYB4 protein is able to bind to DNA motifs known as AC elements, consistent with the hypothesis that PtmyB4 is sufficient to induce lignification, and that it may play this role during wood formation in pine.
348
Ubiquitylation activates a peptidase that promotes cleavage and destabilization of its activating E3 ligases and diverse growth regulatory proteins to limit cell proliferation in Arabidopsis
Hui Dong,Jack Dumenil,Fu Hao Lu,Li Na,Hannes Vanhaeren,Christin Naumann,Maria Klecker,Rachel Prior,Caroline Smith,Neil McKenzie,Gerhard Saalbach,Liangliang Chen,Tian Xia,Nathalie Gonzalez,Mathilde Seguela,Dirk Inzé,Nico Dissmeyer,Yunhai Li,Michael W. Bevan +18 more
TL;DR: It is proposed that DA1 peptidase activity regulates the duration of cell proliferation and the transition to endoreduplication and differentiation during organ formation in plants by coordinating the destabilization of regulatory proteins.
135
Signaling from an Altered Cell Wall to the Nucleus Mediates Sugar-Responsive Growth and Development in Arabidopsis thaliana
Yunhai Li,Caroline Smith,Fiona Corke,Lei-Ying Zheng,Zara Merali,Peter Ryden,Paul Derbyshire,Keith W. Waldron,Michael W. Bevan +8 more
TL;DR: Findings reveal a pathway that signals changes in the cell wall through PRL1 to altered gene expression and sugar-responsive metabolic, growth, and developmental changes in hsr8 mutant plants.
Immunotherapy of melanoma
TL;DR: Tumour immunology is now on solid technical and conceptual footing, however, the challenge remains to apply to patients the results obtained in the laboratories, and to greatly accelerate the development of new anticancer vaccines.
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