Caroline Robberecht
University of Antwerp
6 Papers
99 Citations
Caroline Robberecht is an academic researcher from University of Antwerp. The author has contributed to research in topics: Neurogranin & Internal medicine. The author has an hindex of 6, co-authored 6 publications.
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Papers
C-terminal neurogranin is increased in cerebrospinal fluid but unchanged in plasma in Alzheimer's disease
Ann De Vos,Dirk Jacobs,Hanne Struyfs,Erik Fransen,Kerstin Andersson,Erik Portelius,Ulf Andreasson,Didier De Surgeloose,Daniëlle Hernalsteen,Kristel Sleegers,Caroline Robberecht,Christine Van Broeckhoven,Henrik Zetterberg,Henrik Zetterberg,Kaj Blennow,Sebastiaan Engelborghs,Eugeen Vanmechelen +16 more
TL;DR: In this paper, an enzyme-linked immunosorbent assay (ELISA) targeting neurogranin C-terminally was used to evaluate CSF biomarkers for AD diagnosis.
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The Cerebrospinal Fluid Neurogranin/BACE1 Ratio is a Potential Correlate of Cognitive Decline in Alzheimer's Disease.
Ann De Vos,Hanne Struyfs,Dirk Jacobs,Erik Fransen,Tom Klewansky,Ellen Elisa De Roeck,Ellen Elisa De Roeck,Caroline Robberecht,Christine Van Broeckhoven,Charles Duyckaerts,Sebastiaan Engelborghs,Eugeen Vanmechelen +11 more
TL;DR: This is the first study demonstrating that the CSF neurogranin trunc P75/BACE1 ratio, reflecting postsynaptic/presynaptic integrity, is related to cognitive decline.
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Reduced secreted clusterin as a mechanism for Alzheimer-associated CLU mutations
Karolien Bettens,Steven Vermeulen,Caroline Van Cauwenberghe,Bavo Heeman,Bob Asselbergh,Caroline Robberecht,Sebastiaan Engelborghs,Mathieu Vandenbulcke,Rik Vandenberghe,Peter Paul De Deyn,Peter Paul De Deyn,Marc Cruts,Christine Van Broeckhoven,Kristel Sleegers +13 more
TL;DR: Functional analyses suggest reduced secretion of the CLU protein as the mode of action for three patient-specific CLU mutations, possibly interfering with heterodimerization of the α- and β-chain of CLU.
Genetic variability in SQSTM1 and risk of early-onset Alzheimer dementia: a European early-onset dementia consortium study
Elise Cuyvers,Julie van der Zee,Karolien Bettens,Sebastiaan Engelborghs,Mathieu Vandenbulcke,Caroline Robberecht,Lubina Dillen,Céline Merlin,Nathalie Geerts,Caroline Graff,Caroline Graff,Håkan Thonberg,Håkan Thonberg,Huei Hsin Chiang,Pau Pastor,Pau Pastor,Sara Ortega-Cubero,Sara Ortega-Cubero,Maria A. Pastor,Maria A. Pastor,Janine Diehl-Schmid,Panagiotis Alexopoulos,Luisa Benussi,Roberta Ghidoni,Giuliano Binetti,Benedetta Nacmias,Sandro Sorbi,Raquel Sánchez-Valle,Albert Lladó,Ellen Gelpi,Maria Rosário Almeida,Isabel Santana,Jordi Clarimón,Jordi Clarimón,Alberto Lleó,Alberto Lleó,Juan Fortea,Juan Fortea,Alexandre de Mendonça,Madalena Martins,Barbara Borroni,Alessandro Padovani,Radoslav Matěj,Zdenek Rohan,Agustín Ruiz,Giovanni B. Frisoni,Gian Maria Fabrizi,Rik Vandenberghe,Peter Paul De Deyn,Christine Van Broeckhoven,Kristel Sleegers +50 more
TL;DR: Data indicate that SQSTM1 does not play a major role in the etiology of EOAD, and burden analysis did not reveal an increased frequency of rare variants in EOAD patients in any of the separate study populations nor when meta-analyzing all cohorts.
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Investigating the role of filamin C in Belgian patients with frontotemporal dementia linked to GRN deficiency in FTLD-TDP brains
Jonathan Janssens,Stéphanie Philtjens,Gernot Kleinberger,Sara Van Mossevelde,Julie van der Zee,Rita Cacace,Sebastiaan Engelborghs,Anne Sieben,Anne Sieben,Julia Banzhaf-Strathmann,Lubina Dillen,Céline Merlin,Ivy Cuijt,Caroline Robberecht,Bettina Schmid,Patrick Santens,Adrian Ivanoiu,Mathieu Vandenbulcke,Rik Vandenberghe,Patrick Cras,Peter Paul De Deyn,Peter Paul De Deyn,Jean-Jacques Martin,Stuart Maudsley,Christian Haass,Christian Haass,Marc Cruts,Christine Van Broeckhoven +27 more
TL;DR: Combined quantitative proteomic and bioinformatic analyses of the frontal cortex of FTD patients possessing elevated FLNC levels, identified multiple altered protein factors involved in accelerated aging, neurodegeneration and synaptogenesis.