Caroline P. Le
Monash University
11 Papers
11 Citations
Caroline P. Le is an academic researcher from Monash University. The author has contributed to research in topics: Metastasis & Cancer. The author has an hindex of 8, co-authored 10 publications.
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Papers
Chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination
Caroline P. Le,Cameron J. Nowell,Corina Kim-Fuchs,Edoardo Botteri,Jonathan G. Hiller,Hilmy Ismail,Matthew A. Pimentel,Ming G. Chai,Tara Karnezis,Nicole Rotmensz,Giuseppe Renne,Sara Gandini,Colin W. Pouton,Davide Ferrari,Andreas Möller,Steven A. Stacker,Steven A. Stacker,Erica K. Sloan +17 more
TL;DR: It is shown that chronic stress restructures lymphatic networks within and around tumours to provide pathways for tumour cell escape and that VEGFC derived from tumour cells is required for stress to induce lymphatic remodelling and that this depends on COX2 inflammatory signalling from macrophages.
Chronic stress accelerates pancreatic cancer growth and invasion: A critical role for beta-adrenergic signaling in the pancreatic microenvironment
Corina Kim-Fuchs,Caroline P. Le,Matthew A. Pimentel,David M. Shackleford,Davide Ferrari,Eliane Angst,Frédéric Hollande,Erica K. Sloan,Erica K. Sloan,Erica K. Sloan +9 more
TL;DR: It is indicated that neural β-adrenergic signaling regulates pancreatic cancer progression and β-blockade is suggested as a novel strategy to complement existing therapies for Pancreatic cancer.
β2-Adrenoceptors on tumor cells play a critical role in stress-enhanced metastasis in a mouse model of breast cancer.
Aeson Chang,Caroline P. Le,Adam K. Walker,Sarah J. Creed,Cindy K. Pon,Sabine Albold,Dominic Carroll,Michelle L. Halls,J. Robert Lane,Bernhard Riedel,Davide Ferrari,Erica K. Sloan,Erica K. Sloan,Erica K. Sloan +13 more
TL;DR: It is indicated that it may be necessary to block β2AR on tumor cells to fully control metastatic progression, and a crucial role forβ2AR tumor cell signaling in the adverse effects of stress on metastasis is highlighted.
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Beta-blockade enhances anthracycline control of metastasis in triple-negative breast cancer
Aeson Chang,Edoardo Botteri,Ryan D. Gillis,Lukas Löfling,Caroline P. Le,Alexandra I. Ziegler,Ni-Chun Chung,Matthew C. Rowe,Stewart A. Fabb,Brigham J. Hartley,Cameron J. Nowell,Sasagu Kurozumi,Sara Gandini,Elisabetta Munzone,Emilia Montagna,Nina Eikelis,Sarah E. Phillips,Chikako Honda,Kei Masuda,Ayaka Katayama,Tetsunari Oyama,Steve W. Cole,Gavin W. Lambert,Adam K. Walker,Erica K. Sloan +24 more
TL;DR: Chang et al. as discussed by the authors showed that β2-adrenergic blockade has been associated with improved cancer survival in patients with triple-negative breast cancer (TNBC), but the mechanisms of these effects remain unclear.
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Lymphovascular and neural regulation of metastasis: Shared tumour signalling pathways and novel therapeutic approaches
Caroline P. Le,Tara Karnezis,Tara Karnezis,Marc G. Achen,Marc G. Achen,Marc G. Achen,Steven A. Stacker,Steven A. Stacker,Steven A. Stacker,Erica K. Sloan,Erica K. Sloan,Erica K. Sloan +11 more
TL;DR: The role of blood vessels, lymphatic vessels and nerve fibres in the tumour microenvironment is provided and the interconnected molecular signalling pathways that control their development and activation in cancer are highlighted.
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