Caroline Lamarche
University of British Columbia
43 Papers
70 Citations
Caroline Lamarche is an academic researcher from University of British Columbia. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 8, co-authored 30 publications. Previous affiliations of Caroline Lamarche include Hôpital Maisonneuve-Rosemont & Université de Montréal.
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Papers
Systematic testing and specificity mapping of alloantigen-specific chimeric antigen receptors in regulatory T cells.
Nicholas A.J. Dawson,Caroline Lamarche,Romy E. Hoeppli,Peter Bergqvist,Vivian C.W. Fung,Emma McIver,Qing Huang,Jana Gillies,Madeleine Speck,Paul C. Orban,Jonathan W. Bush,Majid Mojibian,Megan K. Levings +12 more
TL;DR: Systematic testing demonstrated variations in expression, and ability to bind HLA-A*02:01 and stimulate human Treg suppression in vitro, and a new method to comprehensively map the alloantigen specificity of CARs was developed, revealing that humanization reduced Hla-A cross-reactivity.
Donor‐specific chimeric antigen receptor Tregs limit rejection in naive but not sensitized allograft recipients
Antoine Sicard,Caroline Lamarche,Madeleine Speck,May Wong,Isaac Rosado-Sánchez,Mathilde Blois,Nicolas Glaichenhaus,Majid Mojibian,Megan K. Levings +8 more
TL;DR: The finding that donor‐specific CAR‐Tregs restrain de novo but not memory alloreactivity has important implications for their use as an adoptive cell therapy in transplantation.
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Infectious Disease Risk in Dialysis Patients: A Transdisciplinary Approach.
TL;DR: WES in combination with novel technologies, such as RNA sequencing and single-cell RNA sequencing, can provide insight into the molecular mechanisms of disease progression in different monogenic causes of CKD/ESRD and may lead to the development of novel risk-stratification profiles in the future.
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Efficacy of Acute Cellular Rejection Treatment According to Banff Score in Kidney Transplant Recipients: A Systematic Review.
TL;DR: There is a pressing need to standardize outcome metrics for the reversibility of rejection in kidney transplant recipients in order to design high-quality trials for novel therapeutic alternatives.
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Tonic-signaling chimeric antigen receptors drive human regulatory T cell exhaustion.
Caroline Lamarche,Kirsten A. Ward-Hartstonge,Tian Mi,David T.S. Lin,Qing Huang,Andrew Brown,Gherman Novakovsky,Christopher N. Qi,Michael S. Kobor,Caitlin C. Zebley,Evan W. Weber,Crystal L. Mackall,Megan K. Levings +12 more
TL;DR: In this paper , the authors used a method known to induce exhaustion in conventional T cells: expression of a tonic-signaling chimeric antigen receptor (TS-CAR), and found that Tregs rapidly acquired a phenotype that resembled exhaustion and had major changes in their transcriptome, metabolism and epigenome.
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