Caroline L Relton
University of Bristol
442 Papers
923 Citations
Caroline L Relton is an academic researcher from University of Bristol. The author has contributed to research in topics: DNA methylation & Medicine. The author has an hindex of 71, co-authored 394 publications. Previous affiliations of Caroline L Relton include Health Science University & University of Newcastle.
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Papers
Epigenome-wide association study of asthma and wheeze characterizes loci within HK1
Todd M. Everson,Todd M. Everson,Hongmei Zhang,Gabrielle A. Lockett,Akhilesh Kaushal,Melinda Forthofer,Melinda Forthofer,Susan Ewart,Kimberley Burrows,Caroline L Relton,Gemma C Sharp,A. John Henderson,Veeresh Patil,Faisal I. Rezwan,S. Hasan Arshad,S. Hasan Arshad,S. Hasan Arshad,John W. Holloway,Wilfried Karmaus +18 more
TL;DR: Novel associations between asthma and wheeze with methylation at cg16658191 and the expression of HK1 are identified, which may serve as markers of, predictors of, and potentially etiologic factors involved in asthma and early life wheEze.
BMI trajectory in childhood is associated with asthma incidence at young adulthood mediated by DNA methylation.
Rutu Rathod,Hongmei Zhang,Wilfried Karmaus,Susan Ewart,Latha Kadalayil,Caroline L Relton,Caroline L Relton,Susan M. Ring,Susan M. Ring,S. Hasan Arshad,John W. Holloway +10 more
TL;DR: The association of BMI trajectory in childhood with asthma incidence at young adulthood is possibly mediated by DNAm.
Appraising the causal relevance of DNA methylation for risk of lung cancer
Thomas Battram,Rebecca C Richmond,Laura Baglietto,Philip C Haycock,Vittorio Perduca,Stig E. Bojesen,Tom R. Gaunt,Gibran Hemani,Florence Guida,Robert Carreras-Torres,Rayjean J. Hung,Christopher I. Amos,Joshua R. Freeman,Torkjel M. Sandanger,Torunn Hatlen Nøst,Børge G. Nordestgaard,Andrew E. Teschendorff,Silvia Polidoro,Paolo Vineis,Gianluca Severi,Allison M. Hodge,Graham G. Giles,Kjell Grankvist,Mikael Johansson,Mattias Johansson,George Davey Smith,Caroline L Relton +26 more
TL;DR: A two-sample Mendelian randomization analysis provided little evidence that DNA methylation in peripheral blood at the 14 CpG sites play a causal role in lung cancer development, including for cg05575921 AHRR, where methylation is strongly associated with lung cancer risk.
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Collapsed Methylation Quantitative Trait Loci analysis for Low Frequency and Rare variants
Tom G. Richardson,Hashem A. Shihab,Gibran Hemani,Jie Zheng,Eilis Hannon,Jonathan Mill,Jonathan Mill,Elena Carnero-Montoro,Jordana T. Bell,Oliver Lyttleton,Wendy L. McArdle,Susan M. Ring,Santiago Rodriguez,Colin Campbell,George Davey Smith,Caroline L Relton,Nicholas J. Timpson,Tom R. Gaunt +17 more
TL;DR: The potential of this novel approach to mQTL analysis by analysing the combined effect of multiple low frequency or rare variants to identify regions of low frequency and rare variants associated with DNA methylation levels is demonstrated.