Caroline L Relton
University of Bristol
442 Papers
923 Citations
Caroline L Relton is an academic researcher from University of Bristol. The author has contributed to research in topics: DNA methylation & Medicine. The author has an hindex of 71, co-authored 394 publications. Previous affiliations of Caroline L Relton include Health Science University & University of Newcastle.
Chat about Author
Papers
Appraising the causal relevance of DNA methylation for risk of lung cancer
Thomas Battram,Rebecca C Richmond,Laura Baglietto,Philip C Haycock,Vittorio Perduca,Stig E. Bojesen,Stig E. Bojesen,Tom R. Gaunt,Gibran Hemani,Florence Guida,Robert Carreras-Torres,Rayjean J. Hung,Christopher I. Amos,Joshua R. Freeman,Torkjel M. Sandanger,Therese Haugdahl Nøst,Børge G. Nordestgaard,Børge G. Nordestgaard,Andrew E. Teschendorff,Andrew E. Teschendorff,Silvia Polidoro,Paolo Vineis,Gianluca Severi,Gianluca Severi,Gianluca Severi,Allison M. Hodge,Allison M. Hodge,Graham G. Giles,Graham G. Giles,Kjell Grankvist,Mikael Johansson,Mattias Johansson,George Davey Smith,Caroline L Relton +33 more
TL;DR: Previous suggestions of a mediating role of methylation at sites identified in peripheral blood, such as cg05575921-AHRR, could be unfounded, but this study does not preclude the possibility that differential DNAmethylation at other sites is causally involved in lung cancer development, especially within lung tissue.
Novel DNA methylation signatures of tobacco smoking with trans-ethnic effects.
C. Christiansen,Juan E. Castillo-Fernandez,Arce Domingo-Relloso,Arce Domingo-Relloso,Arce Domingo-Relloso,Zhao W,J. S. El-Sayed Moustafa,P-C Tsai,P-C Tsai,P-C Tsai,Jane Maddock,Karin Haack,Shelley A. Cole,Sharon L.R. Kardia,M Molokhia,Matthew Suderman,Chris Power,Caroline L Relton,Caroline L Relton,Andrew Wong,D Kuh,Alissa Goodman,Kerrin S. Small,Jennifer A. Smith,Maria Tellez-Plaza,Ana Navas-Acien,George B. Ploubidis,Rebecca Hardy,Jordana T. Bell +28 more
TL;DR: In this paper, the authors explored novel blood methylation smoking signals on the Illumina MethylationEPIC BeadChip (EPIC) array, which also targets novel CpG-sites in enhancers.
The long-term impact of folic acid in pregnancy on offspring DNA methylation: Follow-up of the Aberdeen folic acid supplementation trial (AFAST)
Rebecca C Richmond,Gemma C Sharp,Georgia Herbert,Charlotte Atkinson,Caroline M Taylor,Sohinee Bhattacharya,Doris M. Campbell,Marion H. Hall,Nabila Kazmi,Tom R. Gaunt,Wendy L. McArdle,Susan M. Ring,George Davey Smith,Andy R Ness,Caroline L Relton +14 more
TL;DR: The results of this study suggest that maternal folic-acid supplement use is associated with changes in the DNA methylation of the offspring that persist for many years after exposure in utero.
Epigenome-wide association study of asthma and wheeze in childhood and adolescence
Ryan Arathimos,Matthew Suderman,Gemma C Sharp,Kimberley Burrows,Raquel Granell,Kate Tilling,Tom R. Gaunt,John Henderson,Susan M. Ring,Rebecca C Richmond,Caroline L Relton +10 more
TL;DR: The majority of observed associations are driven by higher eosinophil cell counts in asthma cases, acting as an intermediate phenotype, with important implications for future studies of DNA methylation in atopic diseases.
DNA methylation of blood cells is associated with prevalent type 2 diabetes in a meta-analysis of four European cohorts.
Diana L Juvinao-Quintero,Riccardo E. Marioni,Carolina Ochoa-Rosales,Carolina Ochoa-Rosales,Tom C. Russ,Ian J. Deary,Joyce B. J. van Meurs,Trudy Voortman,Marie-France Hivert,Gemma C Sharp,Caroline L Relton,Hannah R Elliott +11 more
TL;DR: In this article, a meta-analysis of individual epigenome-wide association studies (EWAS) of prevalent Type 2 diabetes (T2D) conducted in four European studies using peripheral blood DNAm.