Caroline E. Graham
University of Western Australia
4 Papers
12 Citations
Caroline E. Graham is an academic researcher from University of Western Australia. The author has contributed to research in topics: Vascular endothelial growth factor & Diabetic retinopathy. The author has an hindex of 4, co-authored 4 publications. Previous affiliations of Caroline E. Graham include Lions Eye Institute.
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Papers
Laser photocoagulation: ocular research and therapy in diabetic retinopathy.
TL;DR: The principal aim of laser photocoagulation in the treatment of diabetic retinopathy is to effect regression of abnormal vessels, reduce oxygen tension and reverse angiogenesis in the retina.
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Long-term global retinal microvascular changes in a transgenic vascular endothelial growth factor mouse model.
Weiyong Shen,Weiyong Shen,Chooi-May Lai,Caroline E. Graham,Caroline E. Graham,N. Binz,N. Binz,Yvonne K. Y. Lai,Yvonne K. Y. Lai,J. Eade,J. Eade,Diego Guidolin,Domenico Ribatti,Sarah A. Dunlop,Piroska E. Rakoczy +14 more
TL;DR: Analysis of diabetic retinopathy-like changes revealed that these parameters were tightly correlated with the initial degree of vascular leakage; low levels reflected slow and limited retinal microvascular changes in mild cases and high levels reflected more rapid and extensive changes in moderate cases.
Generation of transgenic mice with mild and severe retinal neovascularisation.
Chooi-May Lai,Sarah A. Dunlop,L.A. May,M. Gorbatov,M. Brankov,Weiyong Shen,N. Binz,Yvonne K. Y. Lai,Caroline E. Graham,Chris J Barry,Ian J. Constable,Lyn Beazley,Elizabeth Rakoczy +12 more
TL;DR: Four hVEGF overexpressing transgenic mouse lines with phenotypes ranging from mild to severe neovascularisation are generated to study excess VEGF related molecular and cellular changes and provide additional opportunities to test anti-angiogenic therapies.
Long-term effect of therapeutic laser photocoagulation on gene expression in the eye
N. Binz,N. Binz,Caroline E. Graham,Caroline E. Graham,Ken M. Simpson,Yvonne K. Y. Lai,Yvonne K. Y. Lai,Weiyong Shen,Weiyong Shen,Chooi-May Lai,Terence P. Speed,P. Elizabeth Rakoczy +11 more
TL;DR: Modulated gene expression might contribute to the long‐term inhibitory effect of LPC, and these genes present novel targets for gene‐based therapies aimed at treating microangiopathies, especially diabetic retinopathy, a disease currently only treatable with LPC.