Caroline Courme
Centre national de la recherche scientifique
5 Papers
44 Citations
Caroline Courme is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Triazine & Cyanuric chloride. The author has an hindex of 2, co-authored 5 publications. Previous affiliations of Caroline Courme include Curie Institute.
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Papers
Terminal alkyne-functionalized triazine by Sonogashira coupling: synthesis of a potential cell signalling inhibitor via click chemistry
Caroline Courme,Caroline Courme,Sophie Gillon,Sophie Gillon,Nohad Gresh,Nohad Gresh,Michel Vidal,Michel Vidal,Christiane Garbay,Christiane Garbay,Jean-Claude Florent,Jean-Claude Florent,Emmanuel Bertounesque,Emmanuel Bertounesque +13 more
TL;DR: In this paper, a new method to functionalize a triazine ring using Sonogashira coupling between 2-benzylsulfanyl and trimethylsilylacetylene was described.
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Synthesis of aryl phosphates based on pyrimidine and triazine scaffolds.
Caroline Courme,Nohad Gresh,Nohad Gresh,Michel Vidal,Michel Vidal,Christine Lenoir,Christine Lenoir,Christiane Garbay,Christiane Garbay,Jean-Claude Florent,Jean-Claude Florent,Emmanuel Bertounesque,Emmanuel Bertounesque +12 more
TL;DR: Non-phosphate derivatives encompassing cyclopropane, pyrrole, keto-acid, and IZD fragments were thus step-wise designed and their Grb2-SH2 complexes were modeled by molecular dynamics, and some derivatives gave rise to an enriched pattern of H-bonds and cation-pi interactions with Grb 2- SH2.
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Synthesis of bis-aryl phosphates based on triazine scaffold
TL;DR: In this paper, the synthesis of potential ligands based on the 1,3,5-triazine scaffold bearing two phenylphosphate groups was described for targeting the Grb2-SH2 signaling protein.
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Terminal Alkyne-Functionalized Triazine by Sonogashira Coupling: Synthesis of a Potential Cell Signalling Inhibitor via Click Chemistry.
Caroline Courme,Sophie Gillon,Nohad Gresh,Michel Vidal,Christiane Garbay,Jean-Claude Florent,Emmanuel Bertounesque +6 more
TL;DR: In this article, a new method to functionalize a triazine ring using Sonogashira coupling between 2-benzylsulfanyl and trimethylsilylacetylene was described.
Synthesis of Bis‐Aryl Phosphates Based on Triazine Scaffold.
Caroline Courme,Nohad Gresh,Christine Lenoir,Michel Vidal,Christiane Garbay,Jean-Claude Florent,Emmanuel Bertounesque +6 more
TL;DR: In view of targeting the Grb2-SH2 signaling protein bis-aryl phosphates of type (I) are prepared starting from cyanuric chloride in this article, where they are used to synthesize bis-labeled proteins.