Caroline Chapusot
French Institute of Health and Medical Research
35 Papers
291 Citations
Caroline Chapusot is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Microsatellite instability & Colorectal cancer. The author has an hindex of 17, co-authored 35 publications. Previous affiliations of Caroline Chapusot include University of Burgundy & Johns Hopkins University School of Medicine.
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Papers
Mutations in the RAS-MAPK, PI(3)K (phosphatidylinositol-3-OH kinase) signaling network correlate with poor survival in a population-based series of colon cancers
Ludovic Barault,Nicolas Veyrie,Nicolas Veyrie,Valérie Jooste,Valérie Jooste,Delphine Lecorre,Delphine Lecorre,Caroline Chapusot,Jean Marc Ferraz,Jean Marc Ferraz,Astrid Lièvre,Astrid Lièvre,Marion Cortet,Marion Cortet,Anne Marie Bouvier,Patrick Rat,Patrick Roignot,Jean Faivre,Pierre Laurent-Puig,Pierre Laurent-Puig,F. Piard +20 more
TL;DR: This study is the first report to underline the potential role of RAS‐MAPK, PI (3)K network mutations on survival in colon cancers and the evaluation of its mutations could have clinical implications.
319
Hypermethylator Phenotype in Sporadic Colon Cancer: Study on a Population-Based Series of 582 Cases
Ludovic Barault,Céline Charon-Barra,Valérie Jooste,Mathilde Funes de la Vega,Laurent Martin,Patrick Roignot,Patrick Rat,Anne Marie Bouvier,Pierre Laurent-Puig,Jean Faivre,Caroline Chapusot,F. Piard +11 more
TL;DR: Methylation is an independent prognostic factor in MSS colon cancer and shows the interest of defining three subgroups of patients according to their methylation status (No-CIMP/CIMp-Low/CimP-High).
297
Microsatellite instability and intratumoural heterogeneity in 100 right-sided sporadic colon carcinomas.
Caroline Chapusot,L Martin,Anne Marie Bouvier,Claire Bonithon-Kopp,A Ecarnot-Laubriet,D Rageot,Tibor Ponnelle,P. Laurent Puig,Jean Faivre,F Piard +9 more
TL;DR: It is demonstrated that immunohistochemistry may be as efficient as microsatellite amplification in the detection of unstable phenotype provided that at least two samples of each carcinoma are screened, because of intratumoural heterogeneity.
Structure of MHC class I and class II cDNAs and possible immunodeficiency linked to class II expression in the Mexican axolotl
Annick Tournefier,Véronique Laurens,Caroline Chapusot,Patrick Ducoroy,M. R. Padros,F. Salvudori,B. Sammut +6 more
TL;DR: The sequence analysis shows that the peptide binding region of this class II β chain is relatively well conserved, but most of all does not present any variability in the β domain in inbred as well as in wild axolotls presuming a limited antigenic presentation of few antigenic epitopes.
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HSP110 T17 simplifies and improves the microsatellite instability testing in patients with colorectal cancer
Olivier Buhard,Anaïs Lagrange,Agathe Guilloux,Chrystelle Colas,Mouna Chouchène,Kristell Wanherdrick,Florence Coulet,Erell Guillerm,Coralie Dorard,Laetitia Marisa,A’dem Bokhari,Malorie Greene,Nizar El-Murr,Sahra Bodo,Martine Muleris,Isabelle Sourouille,Magali Svrcek,Pascale Cervera,Hélène Blanché,Jérémie H. Lefevre,Yann Parc,Côme Lepage,Caroline Chapusot,Anne-Marie Bouvier,Marie-Pierre Gaub,Janick Selves,Kerryn Garrett,Barry Iacopetta,Richie Soong,Richard Hamelin,Carmen Garrido,Olivier Lascols,Thierry André,Jean-François Fléjou,Ada Collura,Alex Duval +35 more
TL;DR: HT17 simplifies and improves the current standard molecular methods for detecting MSI in CRC and showed excellent ability to detect MSI in patients with LS.
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