Caroline Albert
Laval University
7 Papers
179 Citations
Caroline Albert is an academic researcher from Laval University. The author has contributed to research in topics: Glucuronidation & Steroid. The author has an hindex of 7, co-authored 7 publications.
Chat about Author
Papers
The monkey and human uridine diphosphate-glucuronosyltransferase UGT1A9, expressed in steroid target tissues, are estrogen-conjugating enzymes.
TL;DR: Northern blot analysis of simian RNA, hybridized with human UGT complementary DNA (cDNA) probes demonstrate the similarity of the transcripts, and it is ascertained that the monkey may be the most appropriate model in which to examine the role of steroid glucuronidation.
107
Comparison of expression and regulation of the high-density lipoprotein receptor SR-BI and the low-density lipoprotein receptor in human adrenocortical carcinoma NCI-H295 cells.
Geneviève Martin,Antoine Pilon,Caroline Albert,Michel Vallé,Dean W. Hum,Jean-Charles Fruchart,Jamila Najib,Véronique Clavey,Bart Staels +8 more
TL;DR: Both the SR-BI and LDL receptor genes are expressed in the human adrenal cortex and coordinately regulated by activators of glucocorticoid synthesis, and both are of major importance in conditions of functional defects in the LDL receptor pathway.
63
Distribution of uridine diphosphate-glucuronosyltransferase (UGT) expression and activity in cynomolgus monkey tissues: evidence for differential expression of steroid-conjugating UGT enzymes in steroid target tissues.
TL;DR: All tissues contained conjugation activity on eugenol, 5α-androstane-3α,17β-diol, androsterone, and 4-hydroxyestradiol, but glucuronidation rates were significantly lower in steroid target tissues than in liver, kidney, or gut.
Glucuronidation of the nonsteroidal antiestrogen EM-652 (SCH 57068), by human and monkey steroid conjugating UDP-glucuronosyltransferase enzymes.
Olivier Barbier,Caroline Albert,Isabelle Martineau,Michel Vallée,Kim High,Fernand Labrie,Dean W. Hum,Claude Labrie,Alain Bélanger +8 more
TL;DR: The present results demonstrate the importance of UGT 1A isoforms, mainly UGT1A1, for EM-652 metabolism in humans and show an interindividual variation of hepaticEM-652 glucuronidation was shown with female human donors.
20
Expression and Regulation of the Lipoprotein Lipase Gene in Human Adrenal Cortex
Bart Staels,Geneviève Martin,Mònica Martínez,Caroline Albert,Julia Peinado-Onsurbe,Régis Saladin,Dean W. Hum,Manuel Reina,Senén Vilaró,Johan Auwerx +9 more
TL;DR: Data indicate that LPL is expressed in human adrenal cortex and regulated in NCI-H295 adrenocortical carcinoma cells by activators of the protein kinase A andprotein kinase C second messenger pathways in a manner comparable to P450scc, which catalyzes the first step in adrenal steroidogenesis.
15