Caroline A. Pearson
University of California, Los Angeles
16 Papers
6 Citations
Caroline A. Pearson is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Biology & Progenitor cell. The author has an hindex of 8, co-authored 13 publications. Previous affiliations of Caroline A. Pearson include University of Sheffield.
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Papers
Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection
Momoko Watanabe,Jessie E. Buth,Neda Vishlaghi,Luis de la Torre-Ubieta,Jiannis Taxidis,Baljit S. Khakh,Giovanni Coppola,Caroline A. Pearson,Ken Yamauchi,Danyang Gong,Xinghong Dai,Robert Damoiseaux,Roghiyh Aliyari,Simone Liebscher,Katja Schenke-Layland,Katja Schenke-Layland,Katja Schenke-Layland,Christine Caneda,Christine Caneda,Eric J. Huang,Ye Zhang,Ye Zhang,Genhong Cheng,Daniel H. Geschwind,Peyman Golshani,Ren Sun,Bennett G. Novitch +26 more
TL;DR: Optimized organoid culture methods are described that efficiently and reliably produce cortical and basal ganglia structures similar to those in the human fetal brain in vivo and are demonstrated for modeling the teratogenic effects of Zika virus on the developing brain and identifying more susceptibility receptors and therapeutic compounds that can mitigate its destructive actions.
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Foxp-Mediated Suppression of N-Cadherin Regulates Neuroepithelial Character and Progenitor Maintenance in the CNS
David Rousso,Caroline A. Pearson,Zachary B. Gaber,Amaya Miquelajauregui,Shanru Li,Carlos Portera-Cailliau,Edward E. Morrisey,Bennett G. Novitch +7 more
TL;DR: Together, these data reveal a Foxp-based transcriptional mechanism that regulates the integrity and cytoarchitecture of neuroepithelial progenitors.
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Late developing cardiac lymphatic vasculature supports adult zebrafish heart function and regeneration
Michael R. Harrison,Xidi Feng,Guqin Mo,Antonio Aguayo,Jessi Villafuerte,Jessi Villafuerte,Tyler Yoshida,Tyler Yoshida,Caroline A. Pearson,Stefan Schulte-Merker,Ching-Ling Lien,Ching-Ling Lien +11 more
TL;DR: It is demonstrated that cardiac lymphatic vessels develop in young adult zebrafish, using coronary arteries to guide their expansion down the ventricle, suggesting that the cardiac lymphatics system can influence the regenerative potential of the myocardium.
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Direct and indirect roles of Fgf3 and Fgf10 in innervation and vascularisation of the vertebrate hypothalamic neurohypophysis.
Fang Liu,Hans-Martin Pogoda,Caroline A. Pearson,Caroline A. Pearson,Kyoji Ohyama,Heiko Löhr,Matthias Hammerschmidt,Marysia Placzek +7 more
TL;DR: Together, the studies suggest a model for the integrated neurohemal wiring of the hypothalamo-neurohypophyseal axis, which exerts early direct effects on endothelial cells that are subsequently complemented by indirect effects on hypothalamic neurosecretory axons.
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TGFβ superfamily signaling regulates the state of human stem cell pluripotency and capacity to create well-structured telencephalic organoids
Momoko Watanabe,Jessie E. Buth,Jillian R. Haney,Neda Vishlaghi,Felix B. Turcios,Lubayna S. Elahi,Wen Gu,Caroline A. Pearson,Arinnae Kurdian,Natella V. Baliaouri,Amanda J. Collier,Osvaldo A. Miranda,N. Dunn,Di Chen,Shan Sabri,L. torre-Ubieta,Amander T. Clark,Kathrin Plath,Heather R. Christofk,Harley I. Kornblum,Michael J. Gandal,Bennett G. Novitch +21 more
TL;DR: In this article , the authors demonstrate that a major contributor to cortical organoid quality is the way hPSCs are maintained prior to differentiation, and identify combinations of TGFβ-related growth factors that are necessary and together sufficient to impart broad telencephalic organoid competency to feeder-free hPSC and enhance the formation of well-structured brain tissues suitable for disease modeling.
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