Noninvasive Assessment of Liver Disease in Patients With Nonalcoholic Fatty Liver Disease.

Non-invasive assessment of non-alcoholic fatty liver disease: Clinical prediction rules and blood-based biomarkers.

Asia–Pacific Working Party on Non-alcoholic Fatty Liver Disease guidelines 2017—Part 1: Definition, risk factors and assessment Vincent Wai-Sun Wong,* Wah-Kheong Chan, Shiv Chitturi, Yogesh Chawla, Yock Young Dan,** Ajay Duseja, Jiangao Fan, Khean-Lee Goh, Masahide Hamaguchi, Etsuko Hashimoto, Seung Up Kim, Laurentius Adrianto Lesmana,*** Yu-Cheng Lin, Chun-Jen Liu, Yen-Hsuan Ni, Jose Sollano, Simon Kin-Hung Wong, Grace Lai-Hung Wong,* Henry Lik-Yuen Chan* and Geoff Farrell *Department ofMedicine and Therapeutics, State Key Laboratory of Digestive Disease andDepartment of Surgery, Department of Surgery, The Chinese University of Hong Kong, Shatin, Hong Kong; Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Gastroenterology and Hepatology Unit, The Canberra Hospital, Canberra, Australian Capital Territory, Australia; Department of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India; **Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Diabetology, Kameoka Municipal Hospital, Kameoka and Departments of InternalMedicine andGastroenterology, TokyoWomen’sMedical University, Tokyo, Japan; Department of InternalMedicine, Institute of Gastroenterology, Yonsei University College ofMedicine, Seoul, Korea; ***Digestive Disease andGI Oncology Centre,Medistra Hospital, Jakarta, Indonesia; Hepatitis Research Center, National Taiwan University, and Department of Internal Medicine, Hepatitis Research Center and Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan; and University of Santo Tomas, Manila, The Philippines

https://onlinelibrary.wiley.com/doi/epdf/10.1111/jgh.13857

Asia-Pacific Working Party on Non-alcoholic Fatty Liver Disease guidelines 2017-Part 1: Definition, risk factors and assessment.

https://www.journal-of-hepatology.eu/article/S0168-8278(12)00890-2/pdf

Non-invasive diagnosis of non-alcoholic fatty liver disease. A critical appraisal

SummaryBackground
Non-alcoholic fatty liver disease (NAFLD) affects 15–40% of the general population. Some patients have non-alcoholic steatohepatitis (NASH) and progressive fibrosis, and would be candidates for monitoring and treatment.

Aim
To review current literature on the use of non-invasive tests to assess the severity of NAFLD.

Methods
Systematic literature searching identified studies evaluating non-invasive tests of NASH and fibrosis using liver biopsy as the reference standard. Meta-analysis was performed for areas with adequate number of publications.

Results
Serum tests and physical measurements like transient elastography (TE) have high negative predictive value (NPV) in excluding advanced fibrosis in NAFLD patients. The NAFLD fibrosis score comprises of six routine clinical parameters and has been endorsed by current American guidelines as a screening test to exclude low-risk individuals. The pooled sensitivities and specificities for TE to diagnose F ≥ 2, F ≥ 3 and F4 disease were 79% and 75%, 85% and 85%, and 92% and 92% respectively. Liver stiffness measurement often fails in obese patients, but the success rate can be improved with the use of the XL probe. A number of biomarkers have been developed for the diagnosis of NASH, but few were independently validated. Serum/plasma cytokeratin-18 fragments have been most extensively evaluated and have a pooled sensitivity of 66% and specificity of 82% in diagnosing NASH.

Conclusions
Current non-invasive tests are accurate in excluding advanced fibrosis in NAFLD patients, and may be used for initial assessment. Further development and evaluation of NASH biomarkers are needed.

https://onlinelibrary.wiley.com/doi/pdf/10.1111/apt.12569

Systematic review with meta-analysis: non-invasive assessment of non-alcoholic fatty liver disease--the role of transient elastography and plasma cytokeratin-18 fragments.

Can we consider immediate complications after thyroidectomy as a quality metric of operation

BackgroundLiver biopsy is considered as the gold standard for assessing nonalcoholic fatty liver disease (NAFLD) histologic lesions in patients with morbid obesity. The aim of this study was to determine the diagnostic utility of noninvasive markers of fibrosis (FibroTest), steatosis (SteatoTest), a

http://journals.lww.com/eurojgh/Documents/Validation_of_noninvasive_biomarkers__FibroTest,.9.pdf

Validation of noninvasive biomarkers (FibroTest, SteatoTest, and NashTest) for prediction of liver injury in patients with morbid obesity.

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Can we consider immediate complications after thyroidectomy as a quality metric of operation

Validation of noninvasive biomarkers (FibroTest, SteatoTest, and NashTest) for prediction of liver injury in patients with morbid obesity.