Carmelo Romano
University of Pennsylvania
8 Papers
489 Citations
Carmelo Romano is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Polyamine & Spermine. The author has an hindex of 8, co-authored 8 publications.
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Papers
Modulation of the NMDA receptor by polyamines
TL;DR: Endogenous polyamines may modulate excitatory synaptic transmission by acting at the polyamine recognition site of the NMDA receptor, which could represent a novel therapeutic target for the treatment of ischemia-induced neurotoxicity, epilepsy, and neurodegenerative diseases.
342
•Journal Article
Effects of polyamines on the binding of [3H]MK-801 to the N-methyl-D-aspartate receptor: pharmacological evidence for the existence of a polyamine recognition site.
TL;DR: It is concluded that these compounds are selective antagonists of the effects of spermine at the NMDA receptor and suggest that there may be a polyamine recognition site on theNMDA receptor complex.
243
Characterization of Polyamines Having Agonist, Antagonist, and Inverse Agonist Effects at the Polyamine Recognition Site of the NMDA Receptor
Keith Williams,Valina L. Dawson,Carmelo Romano,Marc A. Dichter,Marc A. Dichter,Perry B. Molinoff +5 more
TL;DR: It is concluded that DA10 acts as a negative allosteric modulator or inverse agonist at the polyamine recognition site of the NMDA receptor.
193
•Journal Article
Effects of mono-, di-, and triamines on the N-methyl-D-aspartate receptor complex: a model of the polyamine recognition site.
TL;DR: A model of the polyamine recognition site is proposed based on the results of the radioligand binding studies and the computer analysis, and it is documented that these molecules are flexible and long diamines may easily adopt conformations with inter-nitrogen distances mimicking those of short diamines.
23
Characterization of a Mouse β1-Adrenergic Receptor Genomic Clone
Jeffrey A. Cohen,Lee A. Baggott,Carmelo Romano,Motomi Arai,Tamara E. Southerling,Lindon H. Young,Christine A. Kozak,Perry B. Molinoff,Mark I. Greene +8 more
TL;DR: A β1-adrenergic receptor (β1AR) clone was isolated from a BALB/c mouse liver genomic library screened at low stringency with a human brain β2AR cDNA probe.
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