Carmelo Milioto
University of Trento
10 Papers
1 Citations
Carmelo Milioto is an academic researcher from University of Trento. The author has contributed to research in topics: Spinal and bulbar muscular atrophy & Biology. The author has an hindex of 6, co-authored 6 publications. Previous affiliations of Carmelo Milioto include Istituto Italiano di Tecnologia & University of Genoa.
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Papers
Protein Arginine Methyltransferase 6 Enhances Polyglutamine-Expanded Androgen Receptor Function and Toxicity in Spinal and Bulbar Muscular Atrophy
Chiara Scaramuzzino,Ian Casci,Sara Parodi,Sara Parodi,Patricia M.-J. Lievens,Patricia M.-J. Lievens,María José Polanco,María José Polanco,Carmelo Milioto,Carmelo Milioto,Mathilde Chivet,John Monaghan,Ashutosh Mishra,Nisha M. Badders,Tanya Aggarwal,Christopher Grunseich,Fabio Sambataro,Manuela Basso,Frank O. Fackelmayer,J. Paul Taylor,Udai Bhan Pandey,Maria Pennuto,Maria Pennuto +22 more
TL;DR: It is shown here that protein arginine methyltransferase 6 (PRMT6) is a specific co-activator of normal and mutant AR and that the interaction of PRMT6 with AR is significantly enhanced in the AR mutant, which leads to neurodegeneration in cell and fly models of SBMA.
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Protein arginine methyltransferase 1 and 8 interact with FUS to modify its sub-cellular distribution and toxicity in vitro and in vivo.
Chiara Scaramuzzino,John Monaghan,Carmelo Milioto,Nicholas A. Lanson,Astha Maltare,Tanya Aggarwal,Ian Casci,Frank O. Fackelmayer,Maria Pennuto,Udai Bhan Pandey +9 more
TL;DR: It is found that wild type FUS (FUS-WT) specifically interacts with protein arginine methyltransferases 1 and 8 (PRMT1 and PRMT8) and undergoes asymmetric dimethylation in cultured cells, which support a role for arkinine methylation in the pathogenesis of FUS-related ALS.
Glycolytic-to-oxidative fiber-type switch and mTOR signaling activation are early-onset features of SBMA muscle modified by high-fat diet.
Anna Rocchi,Carmelo Milioto,Carmelo Milioto,Sara Parodi,Sara Parodi,Andrea Armirotti,Doriana Borgia,Matteo Pellegrini,Anna Urciuolo,Sibilla Molon,Valeria Morbidoni,Manuela Marabita,Vanina Romanello,Pamela Gatto,Bert Blaauw,Paolo Bonaldo,Fabio Sambataro,Diane M. Robins,Andrew P. Lieberman,Gianni Sorarù,Lodovica Vergani,Marco Sandri,Maria Pennuto,Maria Pennuto +23 more
TL;DR: It is shown that glycolytic muscles were more severely affected than oxidative muscles in SBMA knock-in mice, and an HFD regime is highlighted as a promising approach to support SBMA patients.
Aberrant Autophagic Response in The Muscle of A Knock-in Mouse Model of Spinal and Bulbar Muscular Atrophy.
Paola Rusmini,Paola Rusmini,Maria Josefa Polanco,Riccardo Cristofani,Riccardo Cristofani,Maria Elena Cicardi,Maria Elena Cicardi,Marco Meroni,Marco Meroni,Mariarita Galbiati,Mariarita Galbiati,Margherita Piccolella,Margherita Piccolella,Elio Messi,Elio Messi,Elisa Giorgetti,Andrew P. Lieberman,Carmelo Milioto,Carmelo Milioto,Carmelo Milioto,Anna Rocchi,Tanya Aggarwal,Maria Pennuto,Valeria Crippa,Angelo Poletti,Angelo Poletti +25 more
TL;DR: Alteration in HSPB8-based PQC machinery may represent muscle-specific biomarkers useful to assess SBMA progression in mice and patients in response to pharmacological treatments.
Androgens affect muscle, motor neuron, and survival in a mouse model of SOD1-related amyotrophic lateral sclerosis
Tanya Aggarwal,María José Polanco,Chiara Scaramuzzino,Anna Rocchi,Carmelo Milioto,Carmelo Milioto,Laura Emionite,Emanuela Ognio,Fabio Sambataro,Mariarita Galbiati,Angelo Poletti,Angelo Poletti,Maria Pennuto,Maria Pennuto +13 more
TL;DR: It is shown that androgen ablation by surgical castration extends survival and disease duration of a transgenic mouse model of ALS expressing mutant human SOD1 (hSOD1-G93A) and sheds light on the role of androgens as modifiers of ALS pathogenesis via dysregulation of androgen receptor homeostasis.
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