Carmel G. Teahan
University College London
6 Papers
164 Citations
Carmel G. Teahan is an academic researcher from University College London. The author has contributed to research in topics: HSPA2 & Peptide sequence. The author has an hindex of 6, co-authored 6 publications.
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Papers
Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1.
TL;DR: The active components of purified ω1 are two proteins that associate as heterodimers17, and here it is reported that these are the small GTP-binding protein p21racl and the GDP-dissociation inhibitor rhoGDI.
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The X-linked chronic granulomatous disease gene codes for the β -chain of cytochrome b −245
TL;DR: Almost complete homology was obtained between this sequence and that of the complementary nucleotides 19–147 of the sequence of the X-CGD gene, originally designated as a non-coding region.
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Characterization of the 47-kilodalton autosomal chronic granulomatous disease protein: tissue-specific expression and transcriptional control by retinoic acid.
TL;DR: Nuclear run-on transcription assays show that the gene for p47 is induced at the transcriptional level in a cycloheximide-insensitive manner, indicating that this gene is a primary target for regulation by retinoic acid.
84
Molecular cloning and characterization of grancalcin, a novel EF-hand calcium-binding protein abundant in neutrophils and monocytes.
TL;DR: A novel EF-hand Ca(2+)-binding protein called grancalcin has been identified and characterized, which displays a Ca( 2+)-dependent translocation to the granules and plasma membrane of neutrophils, suggesting that it might play an effector role in the specialized functions of these cells.
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Purification of the 47 kDa phosphoprotein associated with the NADPH oxidase of human neutrophils.
TL;DR: These studies confirm the involvement of this 47 kDa phosphoprotein in the molecular pathology of autosomal recessive CGD and describe a method for the purification of the native protein.
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