Carlos Zaragoza
Universidad Francisco de Vitoria
85 Papers
534 Citations
Carlos Zaragoza is an academic researcher from Universidad Francisco de Vitoria. The author has contributed to research in topics: Medicine & Nitric oxide. The author has an hindex of 30, co-authored 74 publications. Previous affiliations of Carlos Zaragoza include Spanish National Research Council & Johns Hopkins University.
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Papers
Animal models of cardiovascular diseases
Carlos Zaragoza,Carmen Gomez-Guerrero,José Luis Martín-Ventura,Luis Miguel Blanco-Colio,Begoña Lavin,Beñat Mallavia,Carlos Tarin,Sebastian Mas,Alberto Ortiz,Jesús Egido +9 more
TL;DR: Models of atherothrombotic diseases, including expanding and occlusive animal models, as well as models of heart failure are described, which may help to find more efficient and reliable solutions against human cardiovascular diseases.
The role of inducible nitric oxide synthase in the host response to Coxsackievirus myocarditis
Carlos Zaragoza,Christopher J. Ocampo,Marta Saura,Michelle K. Leppo,Xiao-Qing Wei,Richard A. Quick,Salvador Moncada,Foo Y. Liew,Charles J. Lowenstein +8 more
TL;DR: It is shown that Coxsackievirus replicates to higher titers in NOS2(-/-) mice, that the host lacking N OS2 clears virus more slowly than the wild-type host, and that myocarditis is much more severe in infected Nos2(- +/-) mice.
126
Nitric Oxide Regulates Transforming Growth Factor-β Signaling in Endothelial Cells
Marta Saura,Carlos Zaragoza,Beatrice Herranz,Mercedes Griera,Luisa Diez-Marques,Diego Rodríguez-Puyol,Manuel Rodríguez-Puyol +6 more
TL;DR: The results suggest that the endothelial NO/cGMP/PKG pathway interferes with TGF-&bgr;/Smad2 signaling by directing the proteasomal degradation of activated Smad.
125
Activation of the mitogen activated protein kinase extracellular signal-regulated kinase 1 and 2 by the nitric oxide-cGMP-cGMP-dependent protein kinase axis regulates the expression of matrix metalloproteinase 13 in vascular endothelial cells.
Carlos Zaragoza,Estrella Soria,Esther López,Darren D Browning,Milagros Balbín,Carlos López-Otín,Santiago Lamas +6 more
TL;DR: It is proposed that the NO-cGMP-PKG pathway enhances MMP-13 expression by the activation of ERK 1,2, and may be important in the context of pathophysiological conditions such as inflammation or atherogenesis.
98
Matrix metalloproteinase 13 mediates nitric oxide activation of endothelial cell migration.
Esther López-Rivera,Tania R. Lizarbe,Mónica Martínez-Moreno,José M. López-Novoa,Alicia Rodríguez-Barbero,Jose L. Rodrigo,Ana Patricia Fernández,Alberto Álvarez-Barrientos,Santiago Lamas,Carlos Zaragoza +9 more
TL;DR: It is found that exogenous or endogenous NO stimulated EC migration and MMP-13 is an important effector of NO-activated endothelial migration in murine and bovine aortic ECs derived from endothelial NO synthase-deficient mice.
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