Carlos Dedesma
Cornell University
5 Papers
23 Citations
Carlos Dedesma is an academic researcher from Cornell University. The author has contributed to research in topics: Cilium & Cellular differentiation. The author has an hindex of 2, co-authored 2 publications.
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Papers
Facile hyperpolarization chemistry for molecular imaging and metabolic tracking of [1-13C]pyruvate in vivo
Keilian MacCulloch,Austin Browning,David Guarin Bedoya,S. J. McBride,Mustapha B. Abdulmojeed,Carlos Dedesma,Boyd M. Goodson,Matthew S. Rosen,Eduard Y. Chekmenev,Yi-Fen Yen,Patrick TomHon,Thomas Theis +11 more
TL;DR: A first demonstration of SABRE-hyperpolarized contrast detected in vivo, specifically using hyperpolarized [1-13C]pyruvate is described, illustrating the utility of combining lower-cost MRI systems with simple, low-cost hyperpolarization chemistry to develop safe, and scalable molecular imaging.
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Dynein light chain Tctex-1 identifies neural progenitors in adult brain
TL;DR: Tctex‐1, a cytoplasmic dynein light chain, is selectively enriched in almost all cycling progenitors and young neuronal progeny, but not in mature granular cells and astrocytes, in the subgranular zone of the adult dentate gyrus.
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First in vivo experiences with [1-13C]-pyruvate hyperpolarized by SABRE
Thomas Theis,Austin Browning,Keilian MacCulloch,Patrick TomHon,Carlos Dedesma,Boyd M. Goodson,Matthew Rosen,Eduard Chekmenev,David Guarin-Bedoya,Yi-Fen Yen +9 more
Ciliary transition zone activation of phosphorylated Tctex-1 controls ciliary resorption, S-phase entry and fate of neural progenitors.
Aiqun Li,Masaki Saito,Masaki Saito,Jen-Zen Chuang,Yun Yu Tseng,Carlos Dedesma,Kazuhito Tomizawa,Taku Kaitsuka,Ching-Hwa Sung +8 more
TL;DR: Results support a model in which the cilia act as a brake to prevent cell cycle progression, and show the involvement of actin dynamics in Tctex-1-regulated cilium resorption.
Advancing SABRE Toward In Vivo Imaging: Phantom Chemical Conversion of Hyperpolarized [1-13C]-Pyruvate
Patrick TomHon,Keilian MacCulloch,David O. Guarin,Erin Hardy,Austin Browning,Carlos Dedesma,Matthew S. Rosen,Yi-Fen Yen,Thomas Theis +8 more
TL;DR: Researchers advance SABRE hyperpolarized pyruvate for in vivo imaging, demonstrating significant polarization levels enabling dynamic spectroscopy and imaging of downstream chemical products, including pyruvate conversion to pyruvate hydrate and CO2 in a phantom study.