Carlo Girone
University of Eastern Piedmont
5 Papers
Carlo Girone is an academic researcher from University of Eastern Piedmont. The author has contributed to research in topics: Tumor microenvironment & Stromal cell. The author has an hindex of 1, co-authored 2 publications.
Chat about Author
Papers
High-risk HPV oncoproteins E6 and E7 and their interplay with the innate immune response: Uncovering mechanisms of immune evasion and therapeutic prospects.
Irene Lo Cigno,Federica Calati,Carlo Girone,Marta Catozzo,Marisa Gariglio +4 more
TL;DR: High-risk HPV oncoproteins E6 and E7 modulate the innate immune response in epithelial cells and cancer, highlighting the potential for immunotherapeutic interventions.
5
SIRT1 is an actionable target to restore p53 function in HPV-associated cancer therapy.
Irene Lo Cigno,Federica Calati,Carlo Girone,Cinzia Borgogna,Aldo Venuti,Renzo Boldorini,Marisa Gariglio +6 more
TL;DR: The findings uncover an essential role of SIRT1 in HPV-driven oncogenesis, which may have direct translational implications for the treatment of this type of cancer.
3
How Autophagy Shapes the Tumor Microenvironment in Ovarian Cancer.
Alessandra Ferraresi,Carlo Girone,Andrea Esposito,Chiara Vidoni,Letizia Vallino,Eleonora Secomandi,Danny N. Dhanasekaran,Ciro Isidoro +7 more
TL;DR: The role of autophagy is presented, including tumor dormancy, chemoresistance, metastasis, and cell metabolism, with an emphasis on the bidirectional metabolic crosstalk between cancer cells and stromal cells in shaping the OC microenvironment.
Resveratrol Contrasts LPA-Induced Ovarian Cancer Cell Migration and Platinum Resistance by Rescuing Hedgehog-Mediated Autophagy.
Alessandra Ferraresi,Andrea Esposito,Carlo Girone,Letizia Vallino,Amreen Salwa,Ian Ghezzi,Suyanee Thongchot,Suyanee Thongchot,Chiara Vidoni,Danny N. Dhanasekaran,Ciro Isidoro +10 more
TL;DR: In this article, the role of autophagy and resveratrol in ovarian cancer malignancy was investigated, and the ability of RV to counteract Lysophosphatidic acid (LPA) activity.
The RIG-I agonist M8 triggers cell death and natural killer cell activation in human papillomavirus-associated cancer and potentiates cisplatin cytotoxicity.
Carlo Girone,Federica Calati,Irene Lo Cigno,Valentina Salvi,Valentina Tassinari,Tiziana Schioppa,Cinzia Borgogna,Ludovica Lospinoso Severini,John Hiscott,Cristina Cerboni,Alessandra Soriani,Daniela Bosisio,Marisa Gariglio +12 more
TL;DR: In this article , the authors investigated whether RIGI activation by the 5ppp-RNA RIG-I agonist M8 would represent a therapeutically viable option to treat human papillomavirus (HPV)-associated malignancies.