Carla Umansky
Max Planck Society
5 Papers
Carla Umansky is an academic researcher from Max Planck Society. The author has contributed to research in topics: Oxidative stress & Glutathione. The author has an hindex of 2, co-authored 3 publications.
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Papers
Endogenous formaldehyde scavenges cellular glutathione resulting in redox disruption and cytotoxicity
Carla Umansky,Agustín E. Morellato,Matthias Rieckher,Marco Scheidegger,Manuela Romina Martinefski,Gabriela Araceli Fernandez,Oleg Pak,Ksenia Kolesnikova,Hernán Reingruber,Mariela Bollini,Gerry P. Crossan,Natascha Sommer,María Eugenia Monge,Björn Schumacher,Lucas B. Pontel +14 more
TL;DR: This article showed that FA triggers cellular redox imbalance in human cells and in Caenorhabditis elegans, and that FA reacts with the redox-active thiol group of glutathione (GSH), altering GSH:GSSG ratio and causing oxidative stress.
The toxic side of one-carbon metabolism and epigenetics
TL;DR: This work describes recent advances in one-carbon metabolism and epigenetics, focusing on the steps that involve formaldehyde flux and that might lead to cytotoxicity affecting human health.
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Illuminating cellular formaldehyde
TL;DR: Zhu et al. as mentioned in this paper reported the development of a genetically encoded sensor for the detection of formaldehyde in cells and tissues, which has great potential to transform formaldehyde research; illuminating a cellular metabolite that has remained elusive in live structures.
Endogenous formaldehyde scavenges cellular glutathione resulting in cytotoxic redox disruption
Carla Umansky,Agust iacuten Morellato,Marco Scheidegger,Matthias Rieckher,Manuela Romina Martinefski,Gabriela Araceli Fernandez,Ksenia Kolesnikova,Anna Juliane Vesting,Ismene Karakasilioti,Hern aacuten Reingruber,Yan Wei,Rongqiao He,Mariela Bollini,Mar iacutea Eugenia Monge,Bj oumlrn Schumacher,Lucas B. Pontel +15 more
TL;DR: It is shown here that endogenous FA can cause cellular damage beyond genotoxicity by triggering oxidative stress, which is prevented by the enzyme alcohol dehydrogenase 5 (ADH5/GSNOR), which establishes a highly conserved mechanism through which endogenous FA disrupts the GSH-regulated cellular redox homeostasis that is critical during development and aging.
Endogenous formaldehyde scavenges cellular glutathione resulting in redox disruption and cytotoxicity
Carla Umansky,Agustín E. Morellato,Matthias Rieckher,Marco Scheidegger,Manuela Romina Martinefski,Gabriela Araceli Fernandez,Oleg Pak,Ksenia Kolesnikova,Hernán Reingruber,Mariela Bollini,Gerry P. Crossan,Natascha Sommer,María Eugenia Monge,Björn Schumacher,Lucas B. Pontel +14 more
TL;DR: This paper showed that FA triggers cellular redox imbalance in human cells and in Caenorhabditis elegans, and that FA reacts with the redox-active thiol group of glutathione (GSH), altering GSH:GSSG ratio and causing oxidative stress.