Carl A. Stratton
Case Western Reserve University
10 Papers
81 Citations
Carl A. Stratton is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Histone H3 & Histone. The author has an hindex of 10, co-authored 10 publications.
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Papers
Polycomb inhibits histone acetylation by CBP by binding directly to its catalytic domain.
TL;DR: It is reported here that PC inhibits the histone acetyltransferase (HAT) activity of CREB-binding protein (CBP), suggesting that PC/PRC1 inhibition of CBP HAT activity plays a role in regulating transcription of both repressed and active PC-regulated genes.
51
Drosophila ESC-like can substitute for ESC and becomes required for Polycomb silencing if ESC is absent
TL;DR: The larval lethality of esc escl double mutants, together with the lack of phenotypes in the escl mutant, suggests that in wild-type (esc(+)) animals it is the post-embryonic expression of esc, not escl, that is important for development of normal adults.
37
Expression of the Transcription Factor, Spi-1 (PU.1), in Differentiating Murine Erythroleukemia Cells Is Regulated Post-transcriptionally: EVIDENCE FOR DIFFERENTIAL STABILITY OF TRANSCRIPTION FACTOR mRNAs FOLLOWING INDUCER EXPOSURE (∗)
TL;DR: The effect of MeSO on the stability of Spi-1 mRNA provides a novel means of altering gene expression in these cells and is likely to have significance for the differentiation of these cells.
21
RNA polymerase II inhibitor, 5,6-dichloro-1-β-D-ribofuranosylbenzimidazole (DRB) causes erythroleukemic differentiation and transcriptional activation of erythroid genes
TL;DR: It is reported here that 5,6‐dichlorobenzimidazole (DRB), which inhibits RNA polymerase II by causing premature termination of transcription, induces differentiation of these cells, including the transcriptional activation of erythroid genes.
15
The conserved 5'-untranslated leader of Spi-1 (PU.1) mRNA is highly structured and potently inhibits translation in vitro but not in vivo.
TL;DR: A comparison of human and murine cDNA sequences demonstrates that the 5'-untranslated region (5'-UTR) of Spi-1 mRNA is as highly conserved as the coding region (87% identical), suggesting that this sequence may be involved in regulating expression of this protein.