Carina Hellberg
University of Birmingham
36 Papers
564 Citations
Carina Hellberg is an academic researcher from University of Birmingham. The author has contributed to research in topics: Platelet-derived growth factor receptor & Signal transduction. The author has an hindex of 24, co-authored 36 publications. Previous affiliations of Carina Hellberg include Ludwig Institute for Cancer Research & Malmö University.
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Papers
Protein-tyrosine phosphatases and cancer
TL;DR: An improved understanding of how tyrosine phosphorylation function and how they are regulated might aid the development of new anticancer agents.
671
PDGF and Vessel Maturation
TL;DR: Simultaneous inhibition of PDGF receptors on pericytes improves the effect of VEGF inhibitors on endothelial cells and enhances anti-angiogenic therapy.
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VE-PTP regulates VEGFR2 activity in stalk cells to establish endothelial cell polarity and lumen formation
Makoto Hayashi,Arindam Majumdar,Arindam Majumdar,Xiujuan Li,Jeremy Adler,Zuyue Sun,Simona Vertuani,Carina Hellberg,Sofie Mellberg,Sina Koch,Anna Dimberg,Gou Young Koh,Elisabetta Dejana,Heinz-Georg Belting,Markus Affolter,Gavin Thurston,Lars Holmgren,Dietmar Vestweber,Lena Claesson-Welsh +18 more
TL;DR: It is concluded that the role of Tie2 in maintenance of vascular quiescence involves VE-PTP-dependent dephosphorylation of VEGF receptor-2, and that VEGE-cadherin tyrosine phosphorylation, endothelial cell polarity and lumen formation is regulated.
Complement receptor-mediated phagocytosis is associated with accumulation of phosphatidylcholine-derived diglyceride in human neutrophils. Involvement of phospholipase D and direct evidence for a positive feedback signal of protein kinase.
TL;DR: In electropermeabilized cells which were incapable of ingesting particles, C3bi particles were still able to activate PLD and induce formation of diglyceride, indicating that CR-mediated activation of protein kinase C directly triggers a positive feedback mechanism for additionalDiglyceride formation.
117
The PTPμ Protein-tyrosine Phosphatase Binds and Recruits the Scaffolding Protein RACK1 to Cell-Cell Contacts
Tracy Mourton,Carina Hellberg,Susan M. Burden-Gulley,Jason Hinman,Amy C. Rhee,Susann M. Brady-Kalnay +5 more
TL;DR: It is shown that the association of endogenous PTPμ and RACK1 in a lung cell line is increased at high cell density and the recruitment of Rack1 to both the plasma membrane and cell-cell contact sites is dependent upon the presence of the PTP μ protein in these cells.
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