Carina Fischer
Karolinska Institutet
11 Papers
77 Citations
Carina Fischer is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Adipose tissue & White adipose tissue. The author has an hindex of 9, co-authored 11 publications.
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Papers
Pericyte-fibroblast transition promotes tumor growth and metastasis
Kayoko Hosaka,Yunlong Yang,Takahiro Seki,Carina Fischer,Olivier Dubey,Erik Fredlund,Johan Hartman,Piotr Religa,Hiromasa Morikawa,Yoko Ishii,Masakiyo Sasahara,Ola Larsson,Giulio Cossu,Renhai Cao,Sharon Lim,Yihai Cao +15 more
TL;DR: The findings reveal a mechanism of vascular pericytes in PDGF-BB–promoted cancer invasion and metastasis by inducing PFT, and thus targeting PFT may offer a new treatment option in cancer metastasis.
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Molecular mechanisms of IL-33-mediated stromal interactions in cancer metastasis.
Patrik Andersson,Yunlong Yang,Kayoko Hosaka,Yin Zhang,Carina Fischer,Harald Braun,Shuzhen Liu,Guohua Yu,Shihai Liu,Rudi Beyaert,Mayland Chang,Qi Li,Yihai Cao +12 more
TL;DR: Targeting the CAF-TAM-vessel axis provides an outstanding therapeutic opportunity for cancer treatment and provides mechanistic insights on the IL-33-NF-κB-MMP9-laminin axis that mediates theCAF- TAM-committed cancer metastasis.
A miR-327-FGF10-FGFR2-mediated autocrine signaling mechanism controls white fat browning.
Carina Fischer,Takahiro Seki,Sharon Lim,Masaki Nakamura,Patrik Andersson,Yunlong Yang,Jennifer Honek,Yangang Wang,Yanyan Gao,Fang Chen,Nilesh J. Samani,Jun Zhang,Masato Miyake,Seiichi Oyadomari,Akihiro Yasue,Xuri Li,Yun Zhang,Yizhi Liu,Yihai Cao,Yihai Cao,Yihai Cao +20 more
TL;DR: It is shown that miR-327 is downregulated during beiging, which releases FGF10 from inhibition and supports beige adipocyte formation via signaling through FGFR2.
Modulation of age-related insulin sensitivity by VEGF-dependent vascular plasticity in adipose tissues
Jennifer Honek,Takahiro Seki,Hideki Iwamoto,Carina Fischer,Jingrong Li,Sharon Lim,Nilesh J. Samani,Jingwu Zang,Yihai Cao +8 more
TL;DR: It is demonstrated that blood vasculatures in the adipose tissues experience continuous changes during aging and VEGF is a key angiogenic factor controlling microvessel numbers and functions and has therapeutic implications for treatment of obesity and diabetes with anti-VEGF-based antiangiogenic drugs.
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Switching harmful visceral fat to beneficial energy combustion improves metabolic dysfunctions
Xiaoyan Yang,Wenhai Sui,Wenhai Sui,Meng Zhang,Meng Zhang,Mei Dong,Mei Dong,Sharon Lim,Takahiro Seki,Ziheng Guo,Carina Fischer,Huixia Lu,Cheng Zhang,Jianmin Yang,Yangang Wang,Caixia Cao,Yanyan Gao,Xingguo Zhao,Meili Sun,Yuping Sun,Rujie Zhuang,Nilesh J. Samani,Yun Zhang,Yihai Cao,Yihai Cao,Yihai Cao +25 more
TL;DR: In high-fat diet–fed mice, low temperature exposure improved browning of visceral fat, global metabolism via nonshivering thermogenesis, insulin sensitivity, and hepatic steatosis, which could provide a novel therapeutic strategy for treating visceral fat–associated obesity and diabetes.