Cara Clementelli
Icahn School of Medicine at Mount Sinai
8 Papers
12 Citations
Cara Clementelli is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Progenitor cell & Haematopoiesis. The author has an hindex of 1, co-authored 5 publications.
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Papers
TGF-β1 protein trap AVID200 beneficially affects hematopoiesis and bone marrow fibrosis in myelofibrosis
Lilian Varricchio,Camelia Iancu-Rubin,Bhaskar Upadhyaya,Maria Zingariello,Fabrizio Martelli,Paola Verachi,Cara Clementelli,Jean Francois Denis,Adeeb Rahman,Gilles Tremblay,John Mascarenhas,Ruben A. Mesa,Maureen D. O'Connor-McCourt,Anna Rita Migliaccio,Ronald Hoffman +14 more
TL;DR: In this article, the authors showed that myelofibrosis (MF) is a progressive chronic myeloproliferative neoplasm characterized by hyperactivation of JAK/STAT signaling and dysregulation of the transcription factor GATA1 in megakaryocytes.
The hepcidin regulator erythroferrone is a new member of the erythropoiesis-iron-bone circuitry.
Melanie Castro-Mollo,Sakshi Gera,Marc Ruiz-Martinez,Maria Feola,Anisa Gumerova,Marina Planoutene,Cara Clementelli,Veena Sangkhae,Carla Casu,Se-Min Kim,Vaughn Ostland,Huiling Han,Elizabeta Nemeth,Robert E. Fleming,Stefano Rivella,Daria Lizneva,Tony Yuen,Mone Zaidi,Yelena Ginzburg +18 more
TL;DR: In this paper, the authors employ comprehensive skeletal phenotyping analyses as well as functional assays in vitro to address mechanistically the function of Erythroblast erythroblasts (ERFE) in bone.
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The Hepcidin Regulator Erythroferrone is a New Member of the Erythropoiesis-Iron-Bone Circuitry
Melanie Castro-Mollo,Sakshi Gera,Marc Ruiz Martinez,Maria Feola,Anisa Gumerova,Marina Planoutene,Cara Clementelli,Veena Sangkhae,Carla Casu,Se-Min Kim,Vaughn Ostland,Huiling Han,Elizabeta Nemeth,Robert E. Fleming,Stefano Rivella,Daria Lizneva,Tony Yuen,Mone Zaidi,Yelena Ginzburg +18 more
TL;DR: In this paper, the authors reported that ERFE expression in osteoblasts is higher compared with erythroblasts, is independent of erythropoietin, and functional in suppressing hepatocyte hepcidin expression.
Relieving DYRK1A repression of MKL1 confers an adult-like phenotype to human infantile megakaryocytes
Kamaleldin E. Elagib,Ashton T. Brock,Cara Clementelli,Gohar Mosoyan,Lorrie L. Delehanty,Ranjit Sahu,Alexandra Pacheco-Benichou,Corinne Fruit,Thierry Besson,Stephan W. Morris,Koji Eto,Chintan D Jobaliya,Deborah L. French,Paul Gadue,Sandeep Singh,Xinrui Shi,Fujun Qin,Robert Cornelison,Hui Li,Camelia Iancu-Rubin,Ada Goldfarb +20 more
TL;DR: A pharmacologically tractable morphogenetic pathway whose manipulation may alleviate clinical problems associated with the limited thrombopoietic capacity of infantile Mks is delineated.
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Combined Drug Targeting of p53-dependent and -independent Pathways Depletes Myelofibrosis Hematopoietic Stem/Progenitor Cells.
TL;DR: In this article, an imipridone, ONC201, was combined with RG7112, an antagonist of MDM2, a p53 negative regulator, to activate downstream events of the p53 and TNF-related apoptosis-inducing ligand (TRAIL)/death receptor (DR) pathways.