Candice Gurbatri
Columbia University
12 Papers
3 Citations
Candice Gurbatri is an academic researcher from Columbia University. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 3, co-authored 5 publications.
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Papers
Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine.
Leore T. Geller,Michal Barzily-Rokni,Tal Danino,Oliver Jonas,Oliver Jonas,Noam Shental,Deborah Nejman,Nancy Gavert,Yaara Zwang,Zachary A. Cooper,Kevin Shee,Christoph A. Thaiss,Alexandre Reuben,Jonathan Livny,Roi Avraham,Dennie T. Frederick,Matteo Ligorio,Kelly Chatman,Stephen Johnston,Carrie M. Mosher,Alexander Brandis,Garold Fuks,Candice Gurbatri,Vancheswaran Gopalakrishnan,Michael P. Kim,Mark W. Hurd,Matthew H.G. Katz,Jason B. Fleming,Anirban Maitra,David Smith,Matthew Skalak,Jeffrey Bu,Monia Michaud,Sunia A. Trauger,Iris Barshack,Iris Barshack,Talia Golan,Talia Golan,Judith Sandbank,Keith T. Flaherty,Anna Mandinova,Anna Mandinova,Wendy S. Garrett,Wendy S. Garrett,Sarah P. Thayer,Cristina R. Ferrone,Curtis Huttenhower,Curtis Huttenhower,Sangeeta N. Bhatia,Dirk Gevers,Jennifer A. Wargo,Todd R. Golub,Todd R. Golub,Ravid Straussman +53 more
TL;DR: By studying colon cancer models, it is found that bacteria can metabolize the chemotherapeutic drug gemcitabine into its inactive form, 2′,2′-difluorodeoxyuridine, seen primarily in Gammaproteobacteria.
Engineered probiotics for local tumor delivery of checkpoint blockade nanobodies.
Candice Gurbatri,Ioana Lia,Rosa Vincent,Courtney Coker,Samuel Castro,Piper M. Treuting,Taylor E. Hinchliffe,Nicholas Arpaia,Tal Danino +8 more
TL;DR: A single injection of this engineered system demonstrated an enhanced therapeutic response compared to analogous clinically relevant antibodies, resulting in tumor regression in syngeneic mouse models, demonstrating that the engineered probiotic system bridges synthetic biology and immunology to improve upon checkpoint blockade delivery.
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Engineered probiotics for local tumor delivery of checkpoint blockade nanobodies
Candice Gurbatri,Courtney Coker,Taylor E. Hinchliffe,Ioana Lia,Samuel Castro,Piper M. Treuting,Nicholas Arpaia,Tal Danino +7 more
TL;DR: A probiotic platform to locally deliver checkpoint blockade nanobodies to tumors using a controlled lysing mechanism for therapeutic release is designed and results demonstrate that the engineered probiotic system combines innovations in synthetic biology and immunotherapy to improve upon the delivery of checkpoint inhibitors.
Engineering bacteria as interactive cancer therapies
TL;DR: In this article, a review of genetic circuits that enhance spatial and temporal control of therapeutic bacteria to improve their safety and efficacy is presented, and the authors describe the engineering of interactions among bacteria, tumor cells, and immune cells.
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Probiotic-guided CAR-T cells for solid tumor targeting
Rosa Vincent,Candice Gurbatri,Fang-fang Li,Ana Vardoshvili,Courtney Coker,Jong Seong Im,Edward R. Ballister,Mathieu Rouanne,Thomas Savage,Kenia de Los Santos-Alexis,Andrew Redenti,Leonie Brockmann,Meghna Komaranchath,Nicholas Arpaia,Tal Danino +14 more
TL;DR: A platform of probiotic-guided CAR-T cells (ProCARs), in which tumor-colonizing probiotics release synthetic targets that label tumor tissue for CAR-mediated lysis in situ, demonstrated safe and effective in multiple xenograft and syngeneic models of human and mouse cancers.
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