Rapid determination of trace antibiotics is critical for environmental monitoring and the ecosystem. In this study, a sensitive and selective electrochemical sensor for ciprofloxacin (Cip) detectio...

Nanocomposites of Zr(IV)-Based Metal–Organic Frameworks and Reduced Graphene Oxide for Electrochemically Sensing Ciprofloxacin in Water

Optical and Electrochemical Sensors and Biosensors for the Detection of Quinolones

The study combined UHPLC-Q-Orbitrap-MS analysis with authentic standards, to create a novel strategy for isomers recognition and putative identi ﬁ cation. Through the strategy, anti -Covid-19 Jinhua Qinggan Granule was found to comprise 28 isomers and 45 potential anti -Covid-19 constituents. The detection of three constituents (Danshensu, cryptotanshin, and tanshinone IIA) suggests Danshen as con ﬁ dential additive. Based on this, 6 constituents are recommended as quality-marker candidates, including chlorogenic acid, acteoside, peimisine, baicalein, licoricesaponin H2, and tanshinone IIA. Obviously, the study can not only help the public to really understand the Granule ' s formula and chemistry, but also facilitate its Pharmacopoeia collection in future.

pdf/jinhua-qinggan-granule-uhplc-q-extractive-orbitrap-ms-assay-16tf7wo1s1.pdf

Jinhua Qinggan Granule UHPLC-Q-extractive-Orbitrap-MS assay: Putative identification of 45 potential anti-Covid-19 constituents, confidential addition, and pharmacopoeia quality-markers recommendation

Electrochemically pretreated carbon electrodes and their electroanalytical applications – A review

Graphene-based electrochemical sensors for antibiotic detection in water, food and soil: A scientometric analysis in CiteSpace (2011-2021).

Indirect electrochemical determination of ciprofloxacin by anodic stripping voltammetry of Cd(II) on graphene-modified electrode

https://doi.org/10.1016/j.jep.2022.115763

Jinhua Qinggan granules attenuates acute lung injury by promotion of neutrophil apoptosis and inhibition of TLR4/MyD88/NF-κB pathway

ABSTRACT Background Bevacizumab, an inhibitor of angiogenesis, has been approved in several anti-cancer therapies. This study compared the pharmacokinetic (PK) profiles, safety, and immunogenicity of a bevacizumab biosimilar, LY01008, with those of European Union – approved bevacizumab (Avastin®) in healthy Chinese males. Research Design and Methods In this double-blind, open-label, parallel-group study, healthy Chinese male subjects were randomized 1:1 to receive either LY01008 or Avastin® 3 mg/kg intravenously. Primary study endpoints were PK parameters such as the area under the concentration-time curve (AUC) from time zero to infinity (AUC0–∞), AUC from time zero to last quantifiable concentration (AUC0–t), and maximum serum concentration (Cmax). Secondary study endpoints included safety, tolerability, and immunogenicity. Results One hundred and twelve subjects were randomized to receive LY01008 (n = 56) or Avastin® (n = 56). The 90% CIs of the GMRs of AUC0–t, AUC0–∞, and Cmax of LY01008 to Avastin® were all within the bioequivalence margin. Other PK parameters, safety, and immunogenicity profiles were comparable across the two treatment groups. Conclusions This study demonstrated equivalent PK, comparable safety, and similar immunogenicity of LY01008 to Avastin® in healthy subjects, thus paving the way for further clinical evaluation. Trial Registration The trial is registered at ClinicalTrials.gov (CT.gov identifier: NCT05110118).

A randomized, double-blind, parallel-group phase I study comparing the pharmacokinetics, safety, and immunogenicity of LY01008, a candidate bevacizumab biosimilar, with its reference product Avastin® in healthy Chinese male subjects

: Objective: this study aim to explore main active components and possible molecular mechanism of "Lonicerae Japonicae Flos-Forsythiae Fructus" (JYH-LQ) herbal pair in treating acne vulgaris disease by network pharmacology and molecular docking technology. Method: The active components and related targets of “Lonicerae Japonicae Flos-Forsythiae Fructus” herbal pair were obtained from TCMSP Database platform, correcting the official gene symbol names of the targets of the herbal pair from UniProt database. The GeenCards, OMIM and DisGeNET databases were used to find the targets related to acne vulgaris disease. Taking the intersection targets of active components and disease and inputting them into the String database for protein-protein interaction (PPI) network prediction. Then using Cytoscape sofeware to render "effective active components - intersection targets" network prediction. GO annotation and KEGG pathway enrichment analysis for the intersection targets of “Lonicerae Japonicae Flos-Forsythiae Fructus “herbal pair- acne vulgaris disease were performed with DAVID database. Molecular docking between the active components and the key targets was carried out by Autodock. Result: The effective active components of lonicerae japonicae flos-forsythiae fructus herbal Pair in traeting acne vulgaris are quercetin, luteolin, kaempferol. the core targets including TNF, IL-6, TP53. The GO enrichment analysis indicated that the main functions JYH-LQ herbal

/pdf/exploration-on-molecular-mechanism-of-lonicerae-japonicae-2w6nl5bq.pdf

Exploration on Molecular Mechanism of Lonicerae Japonicae Flos-Forsythiae Fructus Herbal Pair in Traeting Acne Vulgaris Based on Network Pharmacology and Molecular Docking Technology

Exploring the mechanism of action of San Huang lotion for the topical treatment of eczema based on network pharmacology and molecular docking techniques

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