Camila V. Esguerra
University of Oslo
63 Papers
175 Citations
Camila V. Esguerra is an academic researcher from University of Oslo. The author has contributed to research in topics: Biology & Zebrafish. The author has an hindex of 25, co-authored 54 publications. Previous affiliations of Camila V. Esguerra include Katholieke Universiteit Leuven & Laboratory of Molecular Biology.
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Papers
A comprehensive assessment of palmatine as anticonvulsant agent - In vivo and in silico studies.
Dorota Nieoczym,Marta Marszalek-Grabska,Radoslaw Szalak,U. Kundap,Agnieszka A. Kaczor,Tomasz M. Wróbel,Nataliia Kosheva,Malgorzata Komar,Michał Abram,Camila V. Esguerra,Eric Samarut,Mateusz Pieróg,Marcin Jakubiec,Krzysztof Kamiński,Wirginia Kukula-Koch,Kinga Gawel +15 more
- 05 Feb 2024
TL;DR: PALM had anticonvulsant effect in ethyl 2-ketopent-4-enoate (EKP)-induced seizure assay in zebrafish larvae as well as in the 6 Hz-induced psychomotor seizure threshold and timed infusion PTZ tests in mice, and the protective effect in the EKP-induced seizure assay was confirmed in the local field potential recordings.
From the North Sea to Drug Repurposing, the Antiseizure Activity of Halimide and Plinabulin
Daniëlle Copmans,Sara Kildgaard,E. Roux,Michèle Partoens,Geert Steurs,Xinhui Wang,Wim M. De Borggraeve,Camila V. Esguerra,Alexander D. Crawford,Thomas Ostenfeld Larsen,Peter de Witte +10 more
TL;DR: The discovery of two new antiseizure compounds, the 2,5-diketopiperazine halimide and its semi-synthetic analogue, plinabulin, and the investigation of two functional analogues, colchicine and indibulin, suggests that microtubule depolymerization does not underpin pl inabulin’s antISEizure action.
Pharmacological Characterization of an Antisense Knockdown Zebrafish Model of Dravet Syndrome: Inhibition of Epileptic Seizures by the Serotonin Agonist Fenfluramine
Yifan Zhang,Angela Kecskés,Daniëlle Copmans,Mélanie Langlois,Alexander D. Crawford,Berten Ceulemans,Lieven Lagae,Peter de Witte,Camila V. Esguerra +8 more
TL;DR: This is the first study demonstrating effective seizure inhibition of fenfluramine in an animal model of Dravet syndrome, and these results provide a basis for identifying novel analogs with improved activity and significantly milder or no side effects.
A critical review of zebrafish schizophrenia models: Time for validation?
TL;DR: It is believed that the zebrafish has high potential also in the area of precision medicine and may complement the development of therapeutics, especially for pharmacoresistant patients.
Integration of Microfractionation, qNMR and zebrafish screening for the in vivo bioassay-guided isolation and quantitative bioactivity analysis of natural products.
Nadine Bohni,Maria Lorena Cordero-Maldonado,Maria Lorena Cordero-Maldonado,Jan Willem Maes,Dany Siverio-Mota,Laurence Marcourt,Sebastian Munck,Appolinary Kamuhabwa,Mainen J. Moshi,Camila V. Esguerra,Peter de Witte,Alexander D. Crawford,Jean-Luc Wolfender +12 more
TL;DR: This study demonstrates that a complete in vivo bioassay-guided fractionation can be performed with only 20 mg of NP extract within a few days, and combines advanced analytical methods with high-content screening in zebrafish to create an integrated platform for microgram-scale, in vivo NP discovery.