Cameron Evans
University of Otago
6 Papers
3 Citations
Cameron Evans is an academic researcher from University of Otago. The author has contributed to research in topics: Cytochrome c oxidase & Membrane potential. The author has an hindex of 4, co-authored 6 publications.
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Papers
A mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury
Tracy A. Prime,Frances H. Blaikie,Cameron Evans,Sergiy M. Nadtochiy,Andrew M. James,Christina C. Dahm,Dario A. Vitturi,Rakesh P. Patel,C. Robin Hiley,Irina Abakumova,Raquel Requejo,Edward T. Chouchani,Thomas R. Hurd,John F. Garvey,Cormac T. Taylor,Paul S. Brookes,Robin A.J. Smith,Michael P. Murphy +17 more
TL;DR: Results support the idea that selectively targeting NO• donors to mitochondria is an effective strategy to reversibly modulate respiration and to protect mitochondria against ischemia-reperfusion injury.
223
Rapid uptake of lipophilic triphenylphosphonium cations by mitochondria in vivo following intravenous injection: implications for mitochondria-specific therapies and probes.
Carolyn M. Porteous,Angela Logan,Cameron Evans,Elizabeth C. Ledgerwood,David K. Menon,Franklin I. Aigbirhio,Robin A.J. Smith,Michael P. Murphy +7 more
TL;DR: Findings greatly extend the utility of mitochondria-targeted lipophilic cations as therapies and probes by attaching functional groups to the TPP cation via long, hydrophobic alkyl chains.
117
(5-Ammonio-pent-yl)triphenyl-phospho-nium dibromide ethanol solvate.
TL;DR: The alkylammonium chain of the dication in the title mitochondrially targeted (5-ammoniopentyl)triphenylphosphonium dibromide ethanol solvate, C23H28NP2+·2Br−·C2H6O, is almost planar and maximizing the P⋯N distance.
2
[3-(Iodo-acetamido)prop-yl]triphenyl-phospho-nium tetra-phenyl-borate.
TL;DR: The title compound, C23H24INOP+·C24H20B−, was prepared by treatment of 3-aminopropyl triphenylphosphonium bromide hydrogen bromides with p-nitrophenyl iodoacetate at 203 K.
1
Assessing the Mitochondrial Membrane Potential in Cells and In Vivo using Targeted Click Chemistry and Mass Spectrometry
Angela Logan,Victoria R. Pell,Karl J. Shaffer,Cameron Evans,Nathan J Stanley,Ellen L. Robb,Tracy A. Prime,Edward T. Chouchani,Helena M. Cochemé,Helena M. Cochemé,Ian M. Fearnley,Sara Vidoni,Andrew M. James,Carolyn M. Porteous,Linda Partridge,Thomas Krieg,Robin A.J. Smith,Michael P. Murphy +17 more
TL;DR: An approach that utilizes two mitochondria-targeted probes each containing a triphenylphosphonium lipophilic cation that drives their accumulation in response to Δψm and the plasma membrane potential is developed, enabling assessment of subtle changes in membrane potentials within cells and in the mouse heart in vivo.