Cameron Ackerley
Sant'Anna School of Advanced Studies
10 Papers
306 Citations
Cameron Ackerley is an academic researcher from Sant'Anna School of Advanced Studies. The author has contributed to research in topics: Ductus arteriosus & Fetus. The author has an hindex of 8, co-authored 10 publications.
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Papers
Carbon monoxide formation in the ductus arteriosus in the lamb: implications for the regulation of muscle tone
Flavio Coceani,Lois Kelsey,Eric Seidlitz,Gerald S. Marks,Brian E. McLaughlin,H J Vreman,David K. Stevenson,Marlene Rabinovitch,Cameron Ackerley +8 more
TL;DR: It is concluded that CO is formed in the ductus and may exert a relaxing influence when its synthesis is upregulated by an appropriate stimulus.
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Endothelin a receptor is necessary for O2 constriction but not closure of ductus arteriosus
Flavio Coceani,Y.-A. Liu,Eric Seidlitz,Lois Kelsey,T. Kuwaki,Cameron Ackerley,Masashi Yanagisawa +6 more
TL;DR: It is concluded that ET-1 mediates the DA constrictor response to O2, however, the vessel still closes postnatally, conceivably caused by the withdrawal of relaxing influence(s).
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Cyclooxygenase-1 and cyclooxygenase-2 in the mouse ductus arteriosus: individual activity and functional coupling with nitric oxide synthase.
Barbara Baragatti,Francesca Brizzi,Cameron Ackerley,Silvia Barogi,Leslie R. Ballou,Flavio Coceani +5 more
TL;DR: It is concluded that the mouse ductus has a complete system for PGE2 synthesis comprising both COX1 and COX2, the two enzymes respond differently to indomethacin but, nevertheless, deletion of either one results in NO upregulation.
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Function of cyclo-oxygenase-1 and cyclo-oxygenase-2 in the ductus arteriosus from foetal lamb: differential development and change by oxygen and endotoxin
TL;DR: While both enzymes contribute to PGE2 formation at term, COX1 is the major isoform in the premature, and COX2, however, may acquire greater importance before‐term following physiological and pathophysiological stimuli.
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Cytochrome P450 during ontogenic development: occurrence in the ductus arteriosus and other tissues.
TL;DR: Findings indicate the presence in the ductus arteriosus of a cy tochrome P450 belonging to the 3A subfamily, however, considering the uneven action of the inducers on enzyme activity in ductal tissue and muscle tone, the role of this cytochrome in closure of the vessel at birth remains to be ascertained.
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