Calvin F. Roff
National Institutes of Health
10 Papers
162 Citations
Calvin F. Roff is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Cholesterol & Intracellular cholesterol transport. The author has an hindex of 9, co-authored 10 publications.
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Papers
The Niemann-Pick C1 Protein Resides in a Vesicular Compartment Linked to Retrograde Transport of Multiple Lysosomal Cargo
Edward B. Neufeld,Meryl E. Wastney,Shutish C. Patel,Sundar Suresh,Adele Cooney,Nancy K. Dwyer,Calvin F. Roff,Kousaku Ohno,Jill A. Morris,Eugene D. Carstea,John P. Incardona,Jerome F. Strauss,Marie T. Vanier,Marc C. Patterson,Roscoe O. Brady,Peter G. Pentchev,E. Joan Blanchette-Mackie +16 more
TL;DR: It is concluded that a distinctive organelle containing NPC1 mediates retrograde lysosomal transport of endocytosed cargo that is not restricted to sterol.
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Progesterone blocks cholesterol translocation from lysosomes.
J D Butler,Joan Blanchette-Mackie,Ehud Goldin,Raymond R. O'Neill,G Carstea,Calvin F. Roff,Marc C. Patterson,S Patel,M E Comly,Adele Cooney +9 more
TL;DR: The progesterone-related inhibition and restoration of lysosomal cholesterol trafficking is a useful experimental means of studying intracellular cholesterol transport and a particularly important feature of its utility is the facile reversibility of the steroid-induced block.
178
Type C Niemann-Pick disease: a murine model of the lysosomal cholesterol lipidosis accumulates sphingosine and sphinganine in liver.
Ehud Goldin,Calvin F. Roff,Stephen P. F. Miller,Claire Rodriguez-Lafrasse,Marie T. Vanier,Roscoe O. Brady,Peter G. Pentchev +6 more
TL;DR: Findings indicate that accumulation of free sphingoid bases is not due to a direct inherent deficiency in the catalytic activity of sphinganine kinase, and may be due to the accumulation of these endogenous hydrophobic amines in lipid laden lysosomes in Niemann-Pick type C mice.
71
The murine Niemann-Pick type C lesion affects testosterone production
Calvin F. Roff,Jerome F. Strauss,Ehud Goldin,Howard Jaffe,M. C. Patterson,George C. Agritellis,Anna Maria Hibbs,Mark Garfield,Roscoe O. Brady,Peter G. Pentchev +9 more
TL;DR: It is concluded that a defect in testicular testosterone production in NPC male mice causes a pleiotropic deficiency in androgen-sensitive expression of proteins in various organs.
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