Callie Knuth
Erasmus University Rotterdam
9 Papers
19 Citations
Callie Knuth is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Mesenchymal stem cell & Endochondral ossification. The author has an hindex of 7, co-authored 9 publications. Previous affiliations of Callie Knuth include Centre for Life.
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Papers
Collagen type X is essential for successful mesenchymal stem cell-mediated cartilage formation and subsequent endochondral ossification.
Callie Knuth,E. Andrés Sastre,Niamh Fahy,Janneke Witte-Bouma,Yanto Ridwan,E M Strabbing,M J Koudstaal,J van de Peppel,Eppo B. Wolvius,Roberto Narcisi,Eric Farrell +10 more
TL;DR: The present study investigated the importance of COLX by shRNA-mediated gene silencing in primary MSCs and found that a significant knock-down ofCOLX disrupted the production of extracellular matrix key components and the secretion profile of chondrogenically differentiated MSCS.
Understanding tissue-engineered endochondral ossification; towards improved bone formation
TL;DR: In this article, the role of donor cells, extracellular matrix and host immune cells during tissue-engineered bone formation is discussed. But the authors focus on mesenchymal stem cells (MSCs)-mediated endochondral bone formation.
Enamel Matrix Derivative has No Effect on the Chondrogenic Differentiation of Mesenchymal Stem Cells.
Lisanne C. Groeneveldt,Callie Knuth,Janneke Witte-Bouma,Fergal J. O'Brien,Eppo B. Wolvius,Eric Farrell +5 more
TL;DR: The use of EMD in combination with chondrogenically primed MSCs for periodontal bone tissue repair is unlikely to have negative effects on MSC differentiation, as well as improving in vivo MSC mediated endochondral bone formation.
Biocompatibility and enhanced osteogenic differentiation of human mesenchymal stem cells in response to surface engineered poly(D,L-lactic-co-glycolic acid) microparticles.
Catherine M Rogers,David J. Deehan,Callie Knuth,Felicity R. A. J. Rose,Kevin M. Shakesheff,Rachel A. Oldershaw +5 more
TL;DR: It is demonstrated that surface engineered PLGA microparticles are an appropriate biomaterial for combining with HF-hMSCs and the selection of PLGA is relevant only when considering the biodegradation time for each biomedical application.
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Investigating the biological response of human mesenchymal stem cells to titanium surfaces
Matthew J. German,Charles Osei-Bempong,Callie Knuth,David J. Deehan,Rachel A. Oldershaw,Rachel A. Oldershaw +5 more
TL;DR: The results suggest that the gross topography of the metal implant is able to create microenvironment niches that have an influence on cellular behaviour, which has implications for the design of advanced tissue engineering strategies that seek to use cellular material to enhance biological remodelling and healing following tissue reconstruction.