Caleb C. Roth
University of Texas at Austin
7 Papers
22 Citations
Caleb C. Roth is an academic researcher from University of Texas at Austin. The author has contributed to research in topics: Membrane & Electrostriction. The author has an hindex of 3, co-authored 7 publications.
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Papers
Role of cytoskeleton and elastic moduli in cellular response to nanosecond pulsed electric fields
TL;DR: It is hypothesize that cellular elasticity, based upon the cytoskeleton, affects nsPEF-induced decrease in cellular viability and that Jurkat cells showed greater lethality than latrunculin-treated CHO cells of comparable elasticity.
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Characterization of acoustic shockwaves generated by exposure to nanosecond electrical pulses
TL;DR: In this article, a noncontact optical technique, termed probe beam deflection technique (PBDT), was used to characterize acoustic shockwaves generated by nsEP traveling through tungsten wire electrodes.
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The role of PIP2 and the IP3/DAG pathway in intracellular calcium release and cell survival during nanosecond electric pulse exposures
TL;DR: The hypothesis that the high electric field itself may be playing a direct role in the hydrolysis of PIP2 from the plasma membrane is supported by using edelfosine to block PLC and prevent activation of the IP3/DAG pathway in Chinese Hamster Ovarian (CHO) cells prior to applying nsPEF.
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Finite element method (FEM) model of the mechanical stress on phospholipid membranes from shock waves produced in nanosecond electric pulses (nsEP)
TL;DR: In this paper, an acoustic shock wave model based on the Helmholtz equation for sound pressure was developed and coupled to a cell membrane model with finite-element modeling in COMSOL.
3
Cells exposed to nanosecond electrical pulses exhibit biomarkers of mechanical stress
Caleb C. Roth,Ronald A. Barnes,Bennett L. Ibey,Hope T. Beier,Erick Moen,Randolph D. Glickman +5 more
TL;DR: In this article, the authors hypothesize that nsEP exposure creates acoustic shock waves capable of causing nanoporation, which could provide the basis for a plausible explanation for electroporation.
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