5 Papers
Caiyan Qi is an academic researcher from University of Electronic Science and Technology of China. The author has contributed to research in topics: Cas9 & Genome editing. The author has an hindex of 5, co-authored 5 publications.
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Papers
Improving Plant Genome Editing with High-Fidelity xCas9 and Non-canonical PAM-Targeting Cas9-NG
Zhaohui Zhong,Simon Sretenovic,Qiurong Ren,Lijia Yang,Yu Bao,Caiyan Qi,Mingzhu Yuan,Yao He,Shishi Liu,Xiaopei Liu,Jiaheng Wang,Lan Huang,Yan Wang,Dibin Baby,David T. Wang,Tao Zhang,Yiping Qi,Yong Zhang +17 more
TL;DR: In this paper, two recently engineered SpCas9 variants, namely xCas9 and Cas9-NG, showed promising potential in improving targeting specificity and broadening the targeting range.
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Single Transcript Unit CRISPR 2.0 Systems for Robust Cas9 and Cas12a Mediated Plant Genome Editing
Xu Tang,Qiurong Ren,Lijia Yang,Yu Bao,Zhaohui Zhong,Yao He,Shishi Liu,Caiyan Qi,Binglin Liu,Yan Wang,Simon Sretenovic,Yingxiao Zhang,Xuelian Zheng,Tao Zhang,Yiping Qi,Yong Zhang,Yong Zhang +16 more
TL;DR: Two new STU CRISPR 2.0 systems for genome editing in rice showed more robust genome editing efficiencies than the first‐generation STU‐Cas9‐RZ system and the conventional mixed dual promoter system, and theSTU‐based PmCDA1 base editor system is highly efficient in rice.
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Enhancement of tanshinone production in Salvia miltiorrhiza hairy root cultures by metabolic engineering
Tao Wei,Tao Wei,Yonghong Gao,Kejun Deng,Lipeng Zhang,Meiling Yang,Xiaopei Liu,Caiyan Qi,Chunguo Wang,Wenqin Song,Yong Zhang,Chengbin Chen +11 more
TL;DR: This study provides an effective strategy for increasing the content of tanshinones and other natural compounds using a combination of genetic engineering and elicitor treatment.
Bidirectional Promoter-Based CRISPR-Cas9 Systems for Plant Genome Editing.
Qiurong Ren,Zhaohui Zhong,Yan Wang,Qi You,Qian Li,Mingzhu Yuan,Yao He,Caiyan Qi,Xu Tang,Xuelian Zheng,Tao Zhang,Yiping Qi,Yong Zhang,Yong Zhang +13 more
TL;DR: A proof-of-concept study of applying BiP systems for expressing two-component CRISPR-Cas9 genome editing reagents in rice and improved the BiP system drastically by using a rice endogenous BiP, OsBiP1.
The Improvement of CRISPR-Cas9 System With Ubiquitin-Associated Domain Fusion for Efficient Plant Genome Editing.
Xuelian Zheng,Caiyan Qi,Lijia Yang,Quan Quan,Binglin Liu,Zhaohui Zhong,Xu Tang,Tingting Fan,Jianping Zhou,Yong Zhang +9 more
TL;DR: Based on the previous single transcription unit genome editing system (STU-SpCas9), using the ubiquitin-associated domain (UBA) to enhance the stability of Cas9 protein, three Cas9-UBA fusion systems are constructed, showing that the fusion of UBA domains did not affect the cleavage mode of Cas 9 protein, and effectively increase the editing efficiency of STU- SpCas9 at the target sites.