Caitlin M. Roake
Stanford University
16 Papers
1 Citations
Caitlin M. Roake is an academic researcher from Stanford University. The author has contributed to research in topics: Telomere & RNA. The author has an hindex of 10, co-authored 15 publications.
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Papers
Regulation of human telomerase in homeostasis and disease.
TL;DR: The transcriptional regulation of human TERT, hTR processing, assembly of the telomerase complex, the cellular localization of telomerases and its recruitment to telomeres, and the regulation of telomersase activity are discussed.
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Characterization of the cell of origin for small cell lung cancer
Kwon-Sik Park,Mei-Chih Liang,David M. Raiser,Raffaella Zamponi,Rebecca R. Roach,Stephen J. Curtis,Zandra E. Walton,Bethany E. Schaffer,Caitlin M. Roake,Anne Flore Zmoos,Christina Kriegel,Kwok-Kin Wong,Julien Sage,Carla F. Kim +13 more
TL;DR: It is found that mouse SCLCs often arise in the lung epithelium, where neuro endocrine cells are located, and that the majority of early lesions were composed of proliferating neuroendocrine cells.
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Regulation of RB Transcription In Vivo by RB Family Members
Deborah L. Burkhart,Lynn K. Ngai,Caitlin M. Roake,Patrick Viatour,Chellappagounder Thangavel,Victoria M. Ho,Erik S. Knudsen,Julien Sage +7 more
TL;DR: It is found that RB family members modulate Rb transcription in specific cell populations in vivo and in culture, and novel regulatory feedback mechanisms within the RB pathway in mammalian cells are identified.
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Acinar cell clonal expansion in pancreas homeostasis and carcinogenesis.
Patrick Neuhöfer,Caitlin M. Roake,Stewart J. Kim,Ryan J. Lu,Robert B. West,Gregory W. Charville,Steven E. Artandi +6 more
TL;DR: In this paper, the authors identify a rare TERT-positive subpopulation of pancreatic acinar cells dispersed throughout the exocrine compartment during homeostasis, which renew the pancreas by forming expanding clones.
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Loss of Human TGS1 Hypermethylase Promotes Increased Telomerase RNA and Telomere Elongation
Lu Chen,Caitlin M. Roake,Alessandra Galati,Francesca Bavasso,Emanuela Micheli,Isabella Saggio,Stefan Schoeftner,Stefano Cacchione,Maurizio Gatti,Steven E. Artandi,Grazia D. Raffa +10 more
TL;DR: It is shown that depletion of trimethylguanosine synthase 1 (TGS1), the enzyme responsible for cap hypermethylation, increases levels of hTR and telomerase, and limits telomere elongation in cultured human cells.
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