Caitlin D. Deane
University of Illinois at Urbana–Champaign
20 Papers
70 Citations
Caitlin D. Deane is an academic researcher from University of Illinois at Urbana–Champaign. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 4, co-authored 4 publications.
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Papers
Engineering unnatural variants of plantazolicin through codon reprogramming
TL;DR: To simultaneously establish the structure-activity relationship of PZN and the substrate tolerance of the biosynthetic pathway, an Escherichia coli expression strain was engineered to heterologously produce PZn analogues, providing insight into the selectivity of post-translational modifying enzymes.
HIV protease inhibitors block streptolysin S production.
Tucker Maxson,Caitlin D. Deane,Evelyn M. Molloy,Courtney L. Cox,Andrew L. Markley,Shaun W. Lee,Douglas A. Mitchell +6 more
TL;DR: It is demonstrated that FDA-approved HIV protease inhibitors, especially nelfinavir, block a key proteolytic processing step during SLS production and will aid in further investigations of the biosynthesis of SLS and related natural products.
In Vitro Biosynthesis and Substrate Tolerance of the Plantazolicin Family of Natural Products
Caitlin D. Deane,Brandon J. Burkhart,Patricia M. Blair,Jonathan I. Tietz,Alice Lin,Douglas A. Mitchell +5 more
TL;DR: Despite increased promiscuity compared to what was previously observed during heterologous production in E. coli, the synthetase retained exquisite selectivity in cyclization of unnatural peptides only at positions which correspond to those cyclized in the natural product.
Cobalamin in charge
TL;DR: A potentially common signaling mechanism across the RTK family that involves LLPS is indicated, which is associated with RTK-mediated intracellular signaling transduction and impaired downstream activation of PKC.
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