Caiping Guo
Tsinghua University
6 Papers
57 Citations
Caiping Guo is an academic researcher from Tsinghua University. The author has contributed to research in topics: PTEN & Tensin. The author has an hindex of 6, co-authored 6 publications.
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Papers
PTEN restoration and PIK3CB knockdown synergistically suppress glioblastoma growth in vitro and in xenografts
Hongbo Chen,Lin Mei,Lanzhen Zhou,Xiaomeng Shen,Caiping Guo,Yi Zheng,Huijun Zhu,Yongqiang Zhu,Laiqiang Huang +8 more
TL;DR: The results demonstrate that PI3 K isoforms play specific roles in tumorigenesis, and that combined treatment of PTEN restoration and PIK3CB siRNA is a promising gene therapy strategy for PTEN-deficient gliomas.
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Potent Anti-Tumor Effect Generated by a Novel Human Papillomavirus (HPV) Antagonist Peptide Reactivating the pRb/E2F Pathway
Caiping Guo,Ke-Wei Liu,Hai-bo Luo,Hongbo Chen,Yi Zheng,Shen-nan Sun,Qian Zhang,Laiqiang Huang +7 more
TL;DR: The current study suggests that this specific peptide may serve as a potential therapeutic agent for HPV16-positive cervical cancer.
A new arylbenzofuran derivative functions as an anti-tumour agent by inducing DNA damage and inhibiting PARP activity
Hongbo Chen,Xiaobin Zeng,Chunmei Gao,Pinghong Ming,Jianping Zhang,Caiping Guo,Lanzhen Zhou,Yin Lu,Lijun Wang,Laiqiang Huang,Xiangjiu He,Lin Mei +11 more
TL;DR: The results indicated that HDAB can function as an anti-cancer agent by inducing DNA damage and inhibiting PARP activity, and molecular docking and in vitro activity assays revealed thatHDAB can correctly dock into the hydrophobic pocket of PARP-1 and suppress PARPs ADP-ribosylation activity.
Moesin-ezrin-radixin-like protein (merlin) mediates protein interacting with the carboxyl terminus-1 (PICT-1)-induced growth inhibition of glioblastoma cells in the nucleus.
Hongbo Chen,Lin Mei,Lanzhen Zhou,Xudong Zhang,Caiping Guo,Junchang Li,H Wang,Yongqiang Zhu,Yi Zheng,Laiqiang Huang +9 more
TL;DR: It is proposed that merlin mediates PICT-1-induced growth inhibition by translocating to the nucleolus and binding PICT (1-356), a carboxyl-terminus truncated mutant that has lost the ability to bind merlin and has a markedly reduced inhibitory effect on the cell cycle and proliferation.
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Apoptosis induced by an antagonist peptide against HPV16 E7 in vitro and in vivo via restoration of p53.
TL;DR: It is demonstrated that the selected peptide can induce E7 degradation and lead to marked apoptosis in HPV16-related cancer cells by activating cellular p53 and its target genes, such as p21.
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