Caffaro Carolina E
10 Papers
30 Citations
Caffaro Carolina E is an academic researcher. The author has contributed to research in topics: Aldesleukin & Interleukin. The author has an hindex of 3, co-authored 10 publications.
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Papers
A semi-synthetic organism that stores and retrieves increased genetic information.
Yorke Zhang,Ptacin Jerod,Emil C. Fischer,Hans R. Aerni,Caffaro Carolina E,Kristine M. San Jose,Aaron W. Feldman,Court R. Turner,Floyd E. Romesberg +8 more
TL;DR: In vivo transcription of DNA containing dNaM and dTPT3 into m RNAs with two different unnatural codons and tRNAs with cognate unnatural anticodons, and their efficient decoding at the ribosome to direct the site-specific incorporation of natural or non-canonical amino acids into superfolder green fluorescent protein are reported.
An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism.
Ptacin Jerod,Caffaro Carolina E,Lina Ma,Kristine M San Jose Gall,Hans R. Aerni,Nicole V Acuff,Rob W Herman,Yelena Pavlova,Michael J. Pena,David B. Chen,Lilia K. Koriazova,Laura K. Shawver,Ingrid B. Joseph,Marcos Milla +13 more
TL;DR: In this article, the authors used an engineered microbial organism with a six-letter semi-synthetic DNA code to generate a library of site-specific, click chemistry compatible amino acid substitutions in the human cytokine IL-2.
Patent
Incorporation of unnatural nucleotides and methods thereof
Ptacin Jerod,Denis A. Malyshev,Caffaro Carolina E +2 more
- 12 Jan 2016
TL;DR: In this paper, methods, composition and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA, wherein the mutant t RNA comprises a mutant anticodon sequence.
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THOR-707, a novel not-alpha IL-2, promotes all key immune system anti-tumoral actions of IL-2 without eliciting vascular leak syndrome (VLS)
Marcos Milla,Ptacin Jerod,Lina Ma,Caffaro Carolina E,Hans R. Aerni,K.M. San Jose,Michael J. Pena,R.W. Herman,Yelena Pavlova,David B. Chen,T.K. Ismaili,S. Li,J. Nguyen,N. Singh,L.K. Shawver,Lilia K. Koriazova,Ingrid B. Joseph +16 more
TL;DR: THOR-707 induction of CD8+ T cell tumor infiltration resulted in single agent dose-dependent anti-tumor efficacy, additive efficacy in combination with a PD-1 checkpoint inhibitor, promoted long-term survival in mice and NHPs and rejection of tumor cells on re-challenge.
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Abstract 3258: THOR-707, a novel not-alpha IL-2, elicits durable pharmacodynamic responses in non-human primates and efficacy as single agent and in combination with anti PD-1 in multiple syngeneic mouse models
Ingrid B. Joseph,Lina Ma,Ptacin Jerod,Caffaro Carolina E,Hans R. Aerni,Kristine M. San Jose,Michael J. Pena,Robert W. Herman,Yelena Pavlova,David B. Chen,Ken Bragstad,Shukuan Li,Jasmine Nguyen,Laura K. Shawver,Lilia K. Koriazova,Marcos Milla +15 more
TL;DR: THOR-707 induction of CD8+ T cell tumor infiltration resulted in single agent dose-dependent anti-tumor efficacy, and additive efficacy in combination with PD-1 checkpoint inhibitor, increasing the survival of CT-26 tumor-bearing mice over either group alone.
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