C.W.I. Douglas
University of Sheffield
31 Papers
340 Citations
C.W.I. Douglas is an academic researcher from University of Sheffield. The author has contributed to research in topics: Porphyromonas gingivalis & Prevotella intermedia. The author has an hindex of 19, co-authored 31 publications.
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Papers
Effect of non-surgical periodontal treatment on clinical parameters and the numbers of Porphyromonas gingivalis, Prevotella intermedia and Actinobacillus actinomycetemcomitans at adult periodontitis sites.
TL;DR: This study demonstrates the usefulness of Q-PCR for enumerating putative pathogens in clinical periodontal specimens and that the numbers of the three organisms in all sites decrease with non-surgicalperiodontal therapy.
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Amylase‐binding as a discriminition among oral streptococci
TL;DR: It is suggested that the ability of organisms to bind salivary amylase could become a key test in identification schemes for certain oral streptococci.
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Identification of Novel Bacteriophages With Therapeutic Potential That Target Enterococcus faecalis
M. Al-Zubidi,Magdalena Widziolek,Magdalena Widziolek,E. K. Court,A. F. Gains,R. E. Smith,Katherine Ansbro,A. Alrafaie,C. Evans,Craig Murdoch,Stéphane Mesnage,C.W.I. Douglas,Andrew Rawlinson,Graham P. Stafford +13 more
TL;DR: The isolation of several bacteriophages that target E. faecalis strains isolated from the oral cavity of patients suffering root canal infections are reported and it is proposed that the phage described here could be used to treat a broad range of antibiotic-resistant E. Faecalis infections.
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Activation of human matrix metalloproteinase 2 by gingival crevicular fluid and Porphyromonas gingivalis.
TL;DR: Findings suggest that P. gingivalis arg-gingipain and neutrophil elastase present in GCF can activate latent MMP-2, which may contribute in vivo to local periodontal tissue destruction.
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Enumeration of Porphyromonas gingivalis, Prevotella intermedia and Actinobacillus actinomycetemcomitans in subgingival plaque samples by a quantitative-competitive PCR method.
TL;DR: The findings indicate that QC-PCR is a useful method for enumerating bacteria in clinical oral specimens and the technique could play a role in the investigation of disease progression.