C. V. Mathiesen
5 Papers
C. V. Mathiesen is an academic researcher. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 3, co-authored 4 publications.
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Papers
The anorectic and thermogenic effects of pharmacological lactate in male mice are confounded by treatment osmolarity and co-administered counterions
Jens Lund,Alberte Wollesen Breum,C. Gil,Sarah Falk,Frederike Sass,Marie S. Isidor,Oksana Dmytriyeva,Pablo Ranea-Robles,C. V. Mathiesen,Astrid L. Basse,O. S. Johansen,Nicole Fadahunsi,Camilla Lund,Trine S. Nicolaisen,Anders B. Klein,Brice Emanuelli,Maximilian Kleinert,Charlotte Mehlin Sorensen,Zachary Gerhart-Hines,Christoffer Clemmensen +19 more
TL;DR: It is shown that the hypertonicity of the injected solutions can drive the metabolic effects attributed to pharmacological administration of lactate, and the importance of taking treatment osmolarity and counterions into account in the experimental design is highlighted.
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Acute and long-term effects of psilocybin on energy balance and feeding behavior in mice
Nicole Fadahunsi,Jens Lund,Alberte Wollesen Breum,C. V. Mathiesen,Isabella Beck Larsen,Gitte M. Knudsen,Anders B. Klein,Christoffer Clemmensen +7 more
TL;DR: In this paper , the effects of psilocybin on feeding behavior, energy metabolism, and as a weight-lowering agent in mice were evaluated in the context of eating disorders.
GLP-1-directed NMDA receptor antagonism for obesity treatment.
Jonas Petersen,Mette Q Ludwig,Vaida Juozaityte,Pablo Ranea-Robles,Charlotte Sashi Aier Svendsen,Eunsang Hwang,Amalie W Kristensen,Nicole Fadahunsi,Jens Lund,Alberte Wollesen Breum,C. V. Mathiesen,Luisa Sachs,Roger Moreno-Justicia,Rebecca L Rohlfs,James C Ford,Jonathan D. Douros,Brian Finan,Bryan Portillo,Kyle C. Grose,Jacob E. Petersen,Mette Trauelsen,Annette Feuchtinger,Richard D. DiMarchi,Thue W. Schwartz,A. S. Deshmukh,Morten B Thomsen,Kristi A Kohlmeier,Tune H. Pers,Bente Frølund,Kristian Strømgaard,Anders B Klein,Christoffer Clemmensen +31 more
TL;DR: Researchers engineered a bimodal molecule combining GLP-1 receptor agonism with NMDA receptor antagonism, effectively reversing obesity, hyperglycemia, and dyslipidemia in rodent models, with targeted delivery circumventing adverse effects associated with MK-801 monotherapy.
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The GDF15-GFRAL pathway is dispensable for the effects of metformin on energy balance
Anders B. Klein,Trine S. Nicolaisen,Kornelia Johann,Andreas M. Fritzen,C. V. Mathiesen,C. Gil,Nanna Skytt Pilmark,Kristian Karstoft,Martin B. Blond,Jonas Salling Quist,Randy J. Seeley,Kristine Færch,Jens Lund,Maximilian Kleinert,Christoffer Clemmensen +14 more
TL;DR: It is corroborate that metformin increases circulating GDF15 in mice and humans, but that it does not reduce voluntary running activity in mice, and suggest that the GDF 15-GFRAL pathway is dispensable for the effects of met formin on energy balance.
Divergent Roles of α5 and β4 Nicotinic Receptor Subunits in Food Reward and Nicotine-induced Weight Loss in Male Mice
Alberte Wollesen Breum,Sarah Falk,Charlotte Sashi Aier Svendsen,Trine S. Nicolaisen,C. V. Mathiesen,Uwe Maskos,Christoffer Clemmensen +6 more
TL;DR: It is demonstrated that 2 nicotinic acetylcholine receptor (nAChR) subunits encoded by the CHRNA5-CHRNA3-CHRNB4 gene cluster, α5 and β4, exhibit divergent roles in food reward, and that β4-containing nAChRs are essential for the weight-lowering effects of nicotine in diet-induced obese mice.