C. V. Kavitha
Indian Institute of Science
16 Papers
126 Citations
C. V. Kavitha is an academic researcher from Indian Institute of Science. The author has contributed to research in topics: Moiety & Chemistry. The author has an hindex of 11, co-authored 16 publications. Previous affiliations of C. V. Kavitha include Government College.
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Papers
Novel derivatives of spirohydantoin induce growth inhibition followed by apoptosis in leukemia cells
C. V. Kavitha,Mridula Nambiar,C. S. Ananda Kumar,Bibha Choudhary,Kalappa Muniyappa,Kanchugarakoppal S. Rangappa,Sathees C. Raghavan +6 more
TL;DR: The mechanism of apoptosis induced by DFH and its implications in leukemia therapy are discussed and the data support the induction of apoptotic by activation of the mitochondrial pathway.
143
Synthesis of 2-(5-((5-(4-chlorophenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid derivatives and evaluation of their cytotoxicity and induction of apoptosis in human leukemia cells.
S. Chandrappa,C. V. Kavitha,M. S. Shahabuddin,K. Vinaya,C. S. Ananda Kumar,S. R. Ranganatha,Sathees C. Raghavan,Kanchugarakoppal S. Rangappa +7 more
TL;DR: It was concluded that the 4th position of the substituted aryl ring plays a dominant role for its anticancer property and two molecules (5e and 5k) having different electron donating group at different positions are rationalized in the induction of cytotoxicity.
98
Synthesis and biological evaluation of novel 1-(4-methoxyphenethyl)-1H-benzimidazole-5-carboxylic acid derivatives and their precursors as antileukemic agents.
N. R. Thimme Gowda,C. V. Kavitha,Kishore K. Chiruvella,Omana Joy,Kanchugarakoppal S. Rangappa,Sathees C. Raghavan +5 more
TL;DR: It is suggested that methyl 1-(4-methoxyphenethyl)-2-fluoro-3-nitrophenyl)-1H-benzimidazole-5-carboxylate (5a) could be a potent anti-leukemic agent.
75
Synthesis and evaluation of 2,5-di(4-aryloylaryloxymethyl)-1,3,4-oxadiazoles as anti-cancer agents.
H.D. Gurupadaswamy,V. Girish,C. V. Kavitha,C. V. Kavitha,Sathees C. Raghavan,Shaukath Ara Khanum +5 more
TL;DR: A series of 2,5-di(4-aryloylaryloxymethyl)-1,3,4-oxadiazoles 9a-j obtained via multistep synthesis from hydroxybenzophenones 4a-e exhibited moderate to good anti-cancer activity.
58
Synthesis and in vitro cytotoxic evaluation of novel diazaspiro bicyclo hydantoin derivatives in human leukemia cells: a SAR study.
C. S. Ananda Kumar,C. V. Kavitha,K. Vinaya,S. B. Benaka Prasad,N. R. Thimmegowda,S. Chandrappa,Sathees C. Raghavan,Kanchugarakoppal S. Rangappa +7 more
TL;DR: The position and number of substituents in benzyl group attached to N−8 of diazaspiro bicyclo hydantoin nucleus interacted selectively with specific targets leading to the difference of biochemical and pharmacological effects.