Background: Metastatic melanoma is the most aggressive form of skin cancer and is raising in incidence every year. The MAPK pathway plays a key role in melanoma development making it an important therapeutic target. FDA-approved kinase inhibitors targeting the mutated BRAF kinase have shown excellent clinical response rates. However, there are limited treatment options for melanomas with mutations in the NRAS kinase. Inhibition of downstream effector molecules (e.g. MEK) have been shown to have limited efficacy. 

ROS induction as a strategy to target persister cancer cell metabolism

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ROS induction as a strategy to target persister cancer cell metabolism