Novel strategies for the formulation and processing of poorly water-soluble drugs.

High hydrostatic pressure treatment for manufacturing of red bean powder: A comparison with the thermal treatment

Drug nanocrystals have been used for a wide range of drug delivery platforms in the pharmaceutical industry, especially for bioavailability enhancement of poorly water-soluble drugs. Wet stirred media milling (WSMM) is the most widely used process for producing dense, stable suspensions of drug nanoparticles, also referred to as nanosuspensions. Despite a plethora of review papers on the production and applications of drug nanosuspensions, modeling of WSMM has not been thoroughly covered in any review paper before. The aim of this review paper is to briefly expose the pharmaceutical scientists and engineers to various modeling approaches, mostly mechanistic, including computational fluid dynamics (CFD), discrete element method (DEM), population balance modeling (PBM), coupled methods, the stress intensity-number model (SI-SN model), and the microhydrodynamic (MHD) model with a main focus on the MHD model for studying the WSMM process. A total of 71 studies, 30 on drugs and 41 on other materials, were reviewed. Analysis of the pharmaceutics literature reveals that WSMM modeling is largely based on empirical, statistically based modeling approaches, and mechanistic modeling could help pharmaceutical engineers develop a fundamental process understanding. After a review of the salient features and various pros-cons of each modeling approach, recent advances in microhydrodynamic modeling and process insights gained therefrom were highlighted. The SI-SN and MHD models were analyzed and critiqued objectively. Finally, the review points out potential research directions such as more mechanistic and accurate CFD-DEM-PBM simulations and the coupling of the MHD-PBM models with the CFD.

Mechanistic Modeling of Wet Stirred Media Milling for Production of Drug Nanosuspensions

https://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/75989/1/Effects%20of%20decreasing%20Water%20Res%20Pan%20Matsui.pdf

Effects of decreasing activated carbon particle diameter from 30 μm to 140 nm on equilibrium adsorption capacity

Model based process optimization of nanosuspension preparation via wet stirred media milling

Impact of formulation and operating parameters on particle size and grinding media wear in wet media milling of organic compounds – A case study for pyrene

The ancient inorganic pigment Egyptian Blue is a fluorophore with outstanding near-infrared (NIR) performance and is thus considered as an emerging optical material that meets the current demand for cheap, efficient, and nontoxic NIR nanofluorophores. Herein, we present a protocol for the quick mass production of Egyptian Blue (CaCuSi4O10) nanosheets (EBNSs) with lateral size down to ∼100 nm by applying state-of-the-art ball-milling techniques. A systematic decay of the NIR photoluminescence behavior with decreasing size of the EBNSs was found, which challenges the desired application of EBNSs as bioimaging markers and other nanoapplications. To pave the way to surface modifications of EBNSs, we deposited a thin layer of silica on the surface of the EBNSs. Taking advantage of this modification, we subsequently performed surface-initiated reversible addition–fragmentation chain transfer (RAFT) polymerization in order to grow both hydrophilic and hydrophobic polymer brushes from EBNSs, which enhanced dispersibility of the nanosheets and even delivered function. By matching the refractive index of the EBNS with its polymer shell, the quality of the NIR photoluminescence of the EBNS could significantly be improved, since disturbing light scattering at the interface could effectively be suppressed. Our results provide a clear picture of the advantages and limitations of EBNSs as optical nanomaterials for NIR fluorescence applications. 

Nanoengineering of Egyptian Blue Nanosheets: Advantages and Limitations for Near-Infrared Photoluminescence Applications

This study presents a simple but effective process route for the production of transparent coatings on glass substrates from inorganic pigment goethite. For this purpose, coating suspensions were prepared by wet milling with a stirred media mill. A water/ethanol mixture was used as the liquid medium to take advantage of the resulting low surface tension for the coating process. In this manner, stable suspensions with particles of down to 50 nm in size were obtained, which already showed a significant increase in transparency. With regard to grinding characteristics, particularly low stress energies proved to be energetically reasonable. The coating step was performed by wet film deposition, achieving coating thicknesses in a range of 0.5–2.5 µm via dip coating. Highly transparent coatings were obtained by applying small particles of 50 nm, which exhibited a significantly lower scattering loss of light (≈3%) in comparison to particles of around 300 nm (70–80%). Additionally, the film color could be adjusted through a variation of the drying temperature due to a conversion of goethite to hematite by dehydration. Since transparency was not affected, this provides an easy-to-implement process adaptation for controlling coating colors.

/pdf/top-down-formulation-of-goethite-nanosuspensions-for-the-2fdj6hgf.pdf

Top-Down Formulation of Goethite Nanosuspensions for the Production of Transparent, Inorganic Glass Coatings

Selective Agglomeration and Separation from Heterogeneous Suspensions of Submicron Particles by Controlling Electrostatic Particle Interactions

Handle everyday research tasks with reliable, citation-backed results

Your personal Research Agent to handle research tasks with citation-backed results

Popular Tasks used by Researchers

How can I help with your research?

Meet SciSpace

Get more enhanced response by uploading the PDFs you want me to reference.

No relevant PDFs in your library

SciSpace is the AI research assistant for academics. Run systematic literature reviews on 280M+ papers, and write papers with cited sources. Trusted by 1M+ students, PhDs & researchers.

SciSpace | AI for Research

Analyze PDFs

Code & Manuscripts

Funding & Grants

Literature & Patents

Medical & Clinical Data

Systematic Review

Visualize & Present

Web & Data

Build a Google Scholar-like website for your research.

Build a website

Create charts and images for your research

Create a Chart

Write a paper for submission to a journal

Draft a manuscript

Patent Search

Design eye-catching scientific posters in minutes.

Scientific Poster Generation

Systematic Literature Review

One task is running at the moment. Your messages will be shown right after.

Drag and drop or click here to browse

Loved by <highlight>1 million+</highlight> researchers

Extract a list of specific topics and their sources from unstructured text

Topics

Compare and analyze relevant papers that matches with your search

Papers

Get insights from PDFs and bookmarked papers from your library

My library

Recent searches

Try searching for:

Catch AI-generated content in scholarly and non-scholarly content

{ai} Detector

Ai Writer

Get PDF Summaries, highlighted text explanations 

Chat with PDF

Effortlessly create in-text citations and bibliographies in APA and 2,500 other formats

Citation generator

Get explanations, summaries, and answers on academic papers

Ease up your research workflow with {scispace}'s cohort of exciting AI tools

Elevate your academic writing skills and convey your ideas the way you want

Paraphraser

Explore our range of reading and writing tools

Your file is being prepared and should be ready in a few minutes. If it's a large file, it might take a bit longer. You can close this window, and we'll email you the file when it's done.

You have reached a maximum limit of <strong>{limit}</strong> columns in the table. Remove at least <strong>1</strong> column to add or create another one.

C. Peppersack

Author Tools

Chat about Author

Papers

Impact of formulation and operating parameters on particle size and grinding media wear in wet media milling of organic compounds – A case study for pyrene

Nanoengineering of Egyptian Blue Nanosheets: Advantages and Limitations for Near-Infrared Photoluminescence Applications

Top-Down Formulation of Goethite Nanosuspensions for the Production of Transparent, Inorganic Glass Coatings

Selective Agglomeration and Separation from Heterogeneous Suspensions of Submicron Particles by Controlling Electrostatic Particle Interactions