15 Papers
280 Citations
C. Merle is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Antibacterial agent & Calcium. The author has an hindex of 10, co-authored 15 publications. Previous affiliations of C. Merle include University of Nantes.
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Papers
Vancomycin encapsulation in biodegradable poly(ε-caprolactone) microparticles for bone implantation. Influence of the formulation process on size, drug loading, in vitro release and cytocompatibility
TL;DR: Vancomycin encapsulation in biodegradable poly(epsilon-caprolactone) microparticles (200 microm mean diameter) was most efficient with a simple emulsion technique that dispersed 122.5 mg/g of polymer.
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A new injectable bone substitute combining poly(ε-caprolactone) microparticles with biphasic calcium phosphate granules
TL;DR: In this article, a triphasic IBS with poly(e-caprolactone) was used for bone replacement in orthopaedic implant and surgical sutures.
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Isostatic compression, a new process for incorporating vancomycin into biphasic calcium phosphate: comparison with a classical method.
TL;DR: Physicochemical studies of BCP and vancomycin showed their structural integrity after isostatic compression, probably because of the porosity decrease of the granules during compression.
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Association of vancomycin and calcium phosphate by dynamic compaction: in vitro characterization and microbiological activity
H. Gautier,Guy Daculsi,C. Merle +2 more
TL;DR: Physicochemical studies of BCP and vancomycin showed their structural integrity after dynamic compaction, which prolonged vancomYcin release time from 1 to 6 days, however, a microbiological assay indicated that van comycin had been altered since only 27.7% was found to be active.
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Biphasic calcium phosphate: a comparative study of interconnected porosity in two ceramics.
TL;DR: The methodology used, which can be applied to the quantification of interconnection in all calcium-phosphate ceramics, constitutes the first step in a complete study of the role of this feature in cellular colonization of the ceramic, matrix dissolution, and drug release from the calcium- phosphate matrix.
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