C. Lopez
Aix-Marseille University
14 Papers
89 Citations
C. Lopez is an academic researcher from Aix-Marseille University. The author has contributed to research in topics: Dopaminergic & Subthalamic nucleus. The author has an hindex of 7, co-authored 14 publications. Previous affiliations of C. Lopez include French Institute of Health and Medical Research.
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Papers
Onset of Pup Locomotion Coincides with Loss of NR2C/D-Mediated Cortico-Striatal EPSCs and Dampening of Striatal Network Immature Activity.
Nathalie Dehorter,François Michel,Thomas Marissal,Yann Rotrou,Yann Rotrou,Boris Matrot,Boris Matrot,C. Lopez,Mark D. Humphries,Constance Hammond +9 more
TL;DR: A silencing of MSNs that timely coincides with locomotion is reported, suggesting that immature MSNs generate immature patterns that are timely shut off to enable the coordination of motor programs.
Progressive motor neuronopathy: a critical role of the tubulin chaperone TBCE in axonal tubulin routing from the Golgi apparatus.
Michael K. E. Schaefer,Henning Schmalbruch,Emmanuelle Buhler,C. Lopez,Natalia Martin,Jean-Louis Guénet,Georg Haase +6 more
TL;DR: It is concluded that motor axons critically depend on axonal tubulin routing from the Golgi apparatus, a process that involves TBCE and possibly other tubulin chaperones.
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Subthalamic nucleus evokes similar long lasting glutamatergic excitations in pallidal, entopeduncular and nigral neurons in the basal ganglia slice
TL;DR: It is proposed that activation of the STN yields comparable long lasting excitations in its target neurons by means of a polysynaptic network.
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Midbrain dopaminergic neurons generate calcium and sodium currents and release dopamine in the striatum of pups
Diana C. Ferrari,Baya Julius Mdzomba,Nathalie Dehorter,C. Lopez,François Michel,Frederic Libersat,Constance Hammond +6 more
TL;DR: It is shown that half of identified E16–P0 mDA neurons spontaneously generate non-synaptic, intrinsically driven Ca2+ spikes andCa2+ plateaus mediated by N- and L-type voltage-gated Ca2 + channels, which suggests that mouse striatal dopaminergic synapses are functional at birth.
Subthalamic Lesion or Levodopa Treatment Rescues Giant GABAergic Currents of PINK1-Deficient Striatum
Nathalie Dehorter,Natalia Lozovaya,Baya Julius Mdzomba,François Michel,C. Lopez,Vera Tsintsadze,Timur Tsintsadze,Michael Klinkenberg,Suzanna Gispert,Georg Auburger,Constance Hammond +10 more
TL;DR: The similarity between the in vitro resting states of Pink1 MSNs and those of fully dopamine (DA)-depleted MSNs of 6-OHDA-treated mice, together with the beneficial effect of levodopa treatment, strongly suggest that dysfunction of mesencephalic dopaminergic neurons in Pink1−/− mice is more severe than expected.
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