Ownby DR, Johnson CC, Peterson EL. JAMA . 2002;288:963–972 

To determine if there is an association between pet exposure in the first year of life and allergy sensitization at age 6 to 7 years.

A prospective birth cohort enrolled from a health maintenance origination in suburban Detroit. Enrolled infants were born between 1987–1989, and followed yearly through age 7 years. Of the 835 enrolled infants, 474 completed the protocol.

After enrollment, families were interviewed for allergic histories. At age 1, the parents were contacted, and …

https://pediatrics.aappublications.org/content/pediatrics/112/Supplement_2/454.2.full.pdf

Long-term relation between breastfeeding and development of atopy and asthma in children and young adults: a longitudinal study

Interactions between ambient air pollution and obesity on lung function in children: The Seven Northeastern Chinese Cities (SNEC) Study

Introduction There is growing interest in the impact of greenness exposure on airway diseases, but the impact of greenness on lung function in children is limited. We aimed to investigate the associations between greenness surrounding schools and lung function in children and whether these associations are modified by air pollution exposure. Methods Between 2012 and 2013, a cross-sectional survey and spirometry were performed among 6740 school children. Lung function patterns were determined as obstructive forced expiratory volume 1 s/forced vital capacity (FEV1/FVC Results Overall, an IQR in NDVI within 500 m was associated with higher FEV1 (+57 mL 95% CI 44 to 70) and FVC (+58 mL 95% CI 43 to 73). NDVI was similarly associated with 25% reduced odds of spirometric restriction (OR: 0.75, 95% CI 0.65 to 0.86). However, among children exposed to the highest compared with the lowest quartile of particulate matter, increasing NDVI was paradoxically associated with lower −40 mL FVC (95% CI −47 to –33, p interaction Discussion Our findings suggest that, in this study population, greening urban areas may promote lung health in low–moderate pollution areas but not in high air pollution areas. If the findings are replicated in other moderate-to-high pollution settings, this highlights a need to have a flexible green policy.

https://thorax.bmj.com/content/thoraxjnl/early/2021/02/25/thoraxjnl-2020-214767.full.pdf

Greenness may improve lung health in low-moderate but not high air pollution areas: seven Northeastern Cities' study

We conducted a cross-sectional study to investigate the associations between recent home renovation exposure and lung function in children. We randomly recruited 7326 school children residing in 24 districts from seven cities in northeastern China. We collected information about home renovations from parents using a questionnaire and lung function measurements from children using spirometer recordings gathered by trained professionals and expressed as the forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), maximal mid-expiratory flow (MMEF), and peak expiratory flow (PEF). We identified higher odds of diminished lung function among these with home renovation in the previous 2 years compared to those without home renovation in the previous 2 years, for FVC (odds ratios [ORs] = 1.84 [95%CI: 1.58, 2.15]; FEV1: ORs = 2.82 [95%CI: 2.36, 3.36]; PEF: ORs = 1.51 [95%CI: 1.24, 1.83]; and MMEF: ORs = 1.90 [95%CI: 1.60, 2.24]). The associations were stronger among children exposed to new polyvinyl chloride (PVC) flooring compared to children exposed to other surface materials. Our results were consistent throughout the analysis of each type of renovation materials. In conclusion, recent home renovation exposure was associated with poor lung function among children. Strategies to protect home owners and their families from respiratory hazards during and after renovation are required.

Impact on Lung Function Among Children Exposed to Home New Surface Materials: The Seven Northeastern Cities Study in China

CJ Lodge, AJ Lowe, LC Gurrin. Clin Exp Allergy. 2012;42(9):1377–1385

To investigate the relationship between pet keeping at birth and the risk of sensitization, wheeze, allergic rhinitis, and eczema over the first 12 years in a cohort selected for familial allergy.

A total of 620 infants were enrolled in a prospective birth cohort in Australia between 1990 and 1994. Eligible infants had at least 1 first-degree family member with a history of eczema, asthma, allergic rhinitis, or severe food allergy.

Data on pet keeping, demographics, and cord blood samples were collected. Demographic information included parental smoking history, presence of carpets in the home, number of siblings, parental history of atopic …

https://pediatrics.aappublications.org/content/pediatrics/132/Supplement_1/S5.1.full.pdf

Pets at Birth Do Not Increase Allergic Disease in At-Risk Children

To evaluate the association between pre-natal and post-natal exposure to pet ownership and lung function in children, a cross-sectional study named Seven Northeastern Cities (SNEC) study was conducted. In this study, children's lung function including the forced expiratory volume in 1 second (FEV1 ), forced vital capacity (FVC), maximal mid-expiratory flow (MMEF), and peak expiratory flow (PEF) were measured by spirometers, and pet ownership situations were collected by questionnaire. Analyzed by multiple logistic regression and generalized linear modeling, we found that for all subjects, pet exposure in the first 2 years of life was significantly associated with lung function impairment of FVC<85% predicted (adjusted odds ratio [aOR]=1.28; 95% confidence interval [CI]: 1.01, 1.63). For current pet exposure, the increased odds of lung function impairment ranged from 35% (aOR=1.35; 95%CI: 1.12, 1.62) for FVC<85% predicted to 57% (aOR=1.57; 95%CI: 1.29, 1.93) for FEV1 <85% predicted. The in utero exposure was not related to lung function impairment. Compared with other pets, higher odds were observed among children with dogs. When stratified by gender, girls with current pet exposure were more likely to have lung function impairment than boys. It implies self-reported exposures to pets were negatively associated with lung function among the children under study.

Pre-natal and post-natal exposure to pet ownership and lung function in children: The Seven Northeastern Cities Study

The time window of pet ownership exposure modifies the relationship of Environmental Tobacco Smoke with lung function: A large population-based cohort study.

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Pre-natal and post-natal exposure to pet ownership and lung function in children: The Seven Northeastern Cities Study

The time window of pet ownership exposure modifies the relationship of Environmental Tobacco Smoke with lung function: A large population-based cohort study.