C. Gregory Sowell
Genentech
23 Papers
229 Citations
C. Gregory Sowell is an academic researcher from Genentech. The author has contributed to research in topics: Bruton's tyrosine kinase & Lipid A. The author has an hindex of 8, co-authored 23 publications.
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Papers
Synthesis and biological evaluation of a new class of vaccine adjuvants: aminoalkyl glucosaminide 4-phosphates (AGPs)
David A. Johnson,C. Gregory Sowell,Craig L. Johnson,Mark T. Livesay,David S. Keegan,Michael J. Rhodes,J. Terry Ulrich,Jon R. Ward,John L. Cantrell,Valerie G. Brookshire +9 more
TL;DR: Several of these compounds enhance the production of tetanus toxoid-specific antibodies in mice and augment vaccine-induced cytotoxic T cells against EG.7-ova target cells.
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Significant Species Difference in Amide Hydrolysis of GDC-0834, a Novel Potent and Selective Bruton's Tyrosine Kinase Inhibitor
Lichuan Liu,Jason Halladay,Young G. Shin,Susan Wong,Melis Coraggio,Hank La,Matthew Baumgardner,Hoa Le,Sashi Gopaul,Jason Boggs,Peter Kuebler,John C. Davis,X. Charlene Liao,Joseph W. Lubach,Alan Deese,C. Gregory Sowell,Kevin S. Currie,Wendy B. Young,S. Cyrus Khojasteh,Cornelis E. C. A. Hop,Harvey Wong +20 more
TL;DR: Uncertainty in human pharmacokinetic prediction and high interest in a BTK inhibitor for clinical evaluation prompted an investigational new drug strategy, in which GDC-0834 was rapidly advanced to a single-dose human clinical trial.
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Potent and selective Bruton's tyrosine kinase inhibitors: Discovery of GDC-0834.
Wendy B. Young,James Barbosa,Peter Blomgren,Meire Bremer,James J. Crawford,Donna Dambach,Steve Gallion,Sarah G. Hymowitz,Kropf Jeffrey E,Seung H. Lee,Lichuan Liu,Joseph W. Lubach,Jen Macaluso,Pat Maciejewski,Brigitte Maurer,Scott A. Mitchell,Daniel F. Ortwine,Julie Di Paolo,Karin Reif,Heleen Scheerens,Aaron C. Schmitt,C. Gregory Sowell,Xiaojing Wang,Harvey Wong,Jin-Ming Xiong,Jianjun Xu,Zhongdong Zhao,Kevin S. Currie +27 more
TL;DR: In human, 2 was found to be highly labile at the exo-cyclic amide bond that links the tetrahydrobenzothiophene moiety to the central aniline ring, resulting in insufficient parent drug exposure, which informed the back-up program and discovery of improved inhibitors.
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Development of a Practical Synthesis of ERK Inhibitor GDC-0994
Xin Linghu,Nicholas Wong,Hans Iding,Vera Jost,Haiming Zhang,Stefan G. Koenig,C. Gregory Sowell,Francis Gosselin +7 more
TL;DR: In this paper, the process development of a synthetic route to manufacture ERK inhibitor GDC-0994 on multikilogram scale was reported, and the API was prepared as the corresponding benzenesulfonate salt in 7 steps and 41% overall yield.
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Chemical Synthesis of the Major Constituents of Salmonella Minnesota Monophosphoryl Lipid A
TL;DR: This work has shown that lipid A constitutes the active principle of lipopoly saccharide (LPS, endotoxin), a complex amphipathic molecule located on the cell surface of Gram-negative bacteria, and the synthesis of lipid A derivatives possessing low toxicity is of great interest.
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