Distal transcutaneous oxygen pressure measurement (TcPo2) is a noninvasive method of evaluating tissular hypoxemia in peripheral arterial disease. The poststress area of hypoxemia is a usefull technique for globally quantifying different parameters represented by TcPo2 curves during exercise. Although its use is increasingly widespread, the reproducibility of this method is poorly documented. TcPo2 was monitored three times at twenty-four hour intervals in 5 patients with stage II obliterative arterial disease during a treadmill walking test. In order to get uniform measurement conditions, each patient remained lying and then stood until TcPo2 became stable. The stress duration was calculated so that the pain step could not be reached. TcPo2 curves were digitized and a specific image analyzer was used to make replicate measurements. The area under the curve was computed, the horizontal axis determining the mean TcPo2 value at rest, the vertical axis representing the end of the exercise period. The corresponding areas under the curves ranged from 34 to 2212 mm2 (573.60; SD 826). Significant correlation coefficients were obtained among replicate measurements (first-second day, first-third day). However, owing to the wide range of area values, the authors decided to compute and use the coefficient of variation (STD/mean), since it was more representative of reproducibility. The mean of its value for 5 patients was 21%. Observation of the examination conditions resulted in several findings, especially the ability of certain patients to adapt their efforts to the exercise. These results indicate that TcPo2 poststress area measurements are reproducible, but the conditions of the exercise have to be rigorously defined and may still be improved.

TcPo2 measurement reproducibility during stress in stage II obliterative arterial disease.

Measurement of transcutaneous oxygen tension (TcPO2) is a noninvasive and easily reproducible method for objectifying and quantifying exercise ischemia in patients with stage II occlusive arterial disease. This technique is also used at rest to evaluate the therapeutic effect of vasoactive treatments. To objectively assess the effectiveness of a vasoactive treatment on the conditions of tissue perfusion, a randomized double-blind study of ifenprodil tartrate versus placebo was performed in 20 patients, whose TcPO2 was continuously measured while they walked on a treadmill. Patients treated with ifenprodil improved significantly as compared with the placebo group, for both the half-hypoxia area, representing the overall evolution of the tissue ischemia (+34.9% and -16.0%, respectively, p = 0.01), and the half-hypoxia recovery time, estimating the postexercise recovery time (+30.2% and -3.6%, respectively, p < 0.05). This study confirms that the continuous measurement of TcPO2 during the recovery phase after exercise represents an objective method for the evaluation and follow-up of patients with stage II intermittent claudication. The results enabled the objective assessment of ifenprodil efficacy on the evolution of tissue hypoxia.

Evaluation of ifenprodil efficacy on exercise-induced tissue ischemia in stage II arteriopathy by measurement of transcutaneous oxygen tension during a standard treadmill test: double-blind study of injectable ifenprodil versus placebo.

Resume L'oxymetrie transcutanee (Tcp0 2 ) dynamique permet d'evaluer la severite de l'arterite des membres inferieurs au stade II. Le but de notre travail etait d'apprecier les variations de la Tcp0 2 chez des patients avec arteriopathie obliterante des membres inferieurs au stade II traites medicalement, avant et apres 6 mois d'incitation a la marche. Dix-sept malades (15 hommes et deux femmes), d'âge moyen 63 ans (extremes : 39–80 ans), ont participe a cette etude. Tous avaient une arteriopathie obliterante des membres inferieurs au stade II de la classification de Leriche et Fontaine. Tous les malades avaient un perimetre de marche stable depuis au moins 3 mois. Chaque malade etait vivement encourage a marcher quotidiennement au moins durant 3 km et l'arret du tabac etait fortement conseille. Le perimetre de marche et les valeurs de Tcp0 2 dynamiques etagees (cuisse, mollet et pied) ont ete etudies avant et apres 6 mois de reeducation. Le perimetre de marche passe en moyenne de 255 m ± 221 avant l'entrainement a la marche, a 835 m ± 539 apres les 6 mois d'entrainement ( P P = 0,02 et P 2 dynamique nous apparait comme une methode fiable d'evaluation de la severite de l'arteriopathie obliterante des membres inferieurs confirmant chez certains patients la persistance d'une ischemie d'effort alors que le perimetre de marche etait devenu illimite.

Suivi par oxymétrie transcutanée dynamique de 17 malades avec artériopathie oblitérante des membres inférieurs au stade II de Leriche et Fontaine

Mesures de la pression transcutanée d'oxygène (TcPO2)

Les escarres restent une pathologie frequente et preoccupante dans les services de geriatrie. Peu d'etudes ont porte sur l'approche des escarres sous l'angle microcirculatoire. C'est l'objet de notre travail a travers l'evaluation d'une nouvelle technique d'exploration de la microcirculation : le Laser-Doppler-Imageur (LDI). Nous avons realise une etude prospective, chez 13 patients de plus de 75 ans, porteurs d'escarres, a partir de photographies macroscopiques et d'images LDI. Les indices de perfusion aux differentes phases de cicatrisation d'une escarre sont fortement liees a l'aspect macroscopique de celle-ci. Nous n'avons pas retrouve de difference significative dans les indices de perfusion aux differents stades de l'escarre. En definitive, le LDI permet une nouvelle approche des escarres et de leur cicatrisation sous l'angle de la recherche en microcirculation. Son utilisation courante (valeur predictive des indices de perfusion et suivi des escarres) n'a pas ete validee dans notre etude, mais ces resultats doivent etre confirmes sur une plus grande population.

Étude microcirculatoire des escarres : apport du laser doppler imageur

Dans ce travail, nous rapportons les resultats de la mesure de la TcPO 2 au cours d'une epreuve d'effort standardisee, dans un groupe de patients atteints d'une arteriopathie de stade II. L'utilisation simultanee de plusieurs capteurs a permis d'une part une mesure polyetagee: cuisse, mollet, pied, pour tenter de preciser la topographie de l'hypoxie, d'autre part la mise en place d'une electrode precordiale de reference indispensable pour eliminer les variations de TcPO 2 liees a l'adaptat-ion cardio-respiratoire du sujet

Intérêt de l'oxymétrie transcutanée dynamique étagée dans l'artérite des membres inférieurs de stade II.

The clinical and prognostic value of transcutaneous oxygen pressure measurements at rest has been established in Leriche Stage III and IV occlusive peripheral arterial disease but is controversial in Stage II because there is an overlap of transcutaneous pO2 (Tc pO2) values with those of normal subjects. The authors report the results of Tc pO2 measurements during exercise testing in a group of patients with Stage II occlusive arterial disease of the lower limbs. Seventy-eight patients with an average age of 53 years (range 40 to 65 years) whose claudication perimeter and site of pain had been carefully assessed and who had also recently undergone Doppler arterial examination and arteriography and 35 control subjects with an average age of 54 years (range 45 to 70 years) were studied. The Tc pO2 was continuously measured with a multimodular Kontron Supermon at 4 different sites simultaneously: precordium (reference probe), thigh, calf and foot in the dorsal recumbent position after 30 minutes rest, during a standardised exercise stress test at 50 watts and during the recovery phase. The results were expressed as ratio of tissue oxygenation (RTO): thigh, calf or foot Tc pO2/precordial Tc pO2 X 100 in order to take into account the patients cardiorespiratory status and adaptation to exercise. The RTO in normal subjects remained at the upper limits of the resting value throughout exercise and then returned slowly to basal values during the recovery phase.(ABSTRACT TRUNCATED AT 250 WORDS)

Value of transcutaneous staged dynamic oximetry of stage II arteritis of the leg

Handle everyday research tasks with reliable, citation-backed results

Your personal Research Agent to handle research tasks with citation-backed results

Popular Tasks used by Researchers

How can I help with your research?

Meet SciSpace

Get more enhanced response by uploading the PDFs you want me to reference.

No relevant PDFs in your library

SciSpace is the AI research assistant for academics. Run systematic literature reviews on 280M+ papers, and write papers with cited sources. Trusted by 1M+ students, PhDs & researchers.

SciSpace | AI for Research

Analyze PDFs

Code & Manuscripts

Funding & Grants

Literature & Patents

Medical & Clinical Data

Systematic Review

Visualize & Present

Web & Data

Build a Google Scholar-like website for your research.

Build a website

Create charts and images for your research

Create a Chart

Write a paper for submission to a journal

Draft a manuscript

Patent Search

Design eye-catching scientific posters in minutes.

Scientific Poster Generation

Systematic Literature Review

One task is running at the moment. Your messages will be shown right after.

Drag and drop or click here to browse

Loved by <highlight>1 million+</highlight> researchers

Extract a list of specific topics and their sources from unstructured text

Topics

Compare and analyze relevant papers that matches with your search

Papers

Get insights from PDFs and bookmarked papers from your library

My library

Recent searches

Try searching for:

Catch AI-generated content in scholarly and non-scholarly content

{ai} Detector

Ai Writer

Get PDF Summaries, highlighted text explanations 

Chat with PDF

Effortlessly create in-text citations and bibliographies in APA and 2,500 other formats

Citation generator

Get explanations, summaries, and answers on academic papers

Ease up your research workflow with {scispace}'s cohort of exciting AI tools

Elevate your academic writing skills and convey your ideas the way you want

Paraphraser

Explore our range of reading and writing tools

Your file is being prepared and should be ready in a few minutes. If it's a large file, it might take a bit longer. You can close this window, and we'll email you the file when it's done.

You have reached a maximum limit of <strong>{limit}</strong> columns in the table. Remove at least <strong>1</strong> column to add or create another one.

C Grard

Author Tools

Chat about Author

Papers

Intérêt de l'oxymétrie transcutanée dynamique étagée dans l'artérite des membres inférieurs de stade II.

Suivi par oxymétrie transcutanée dynamique de 17 malades avec artériopathie oblitérante des membres inférieurs au stade II de Leriche et Fontaine

Value of transcutaneous staged dynamic oximetry of stage II arteritis of the leg