C. Gluchowski
United States Military Academy
7 Papers
79 Citations
C. Gluchowski is an academic researcher from United States Military Academy. The author has contributed to research in topics: GABA transporter & GABA Uptake Inhibitors. The author has an hindex of 5, co-authored 7 publications.
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Papers
Design and Synthesis of Novel α1a Adrenoceptor-Selective Dihydropyridine Antagonists for the Treatment of Benign Prostatic Hyperplasia
Dhanapalan Nagarathnam,John M. Wetzel,Shou Wu Miao,Mohammad R. Marzabadi,George Chiu,Wai C. Wong,Xingfang Hong,James Fang,Carlos Forray,T. A. Branchek,William E. Heydorn,Raymond S.L. Chang,Theodore P. Broten,Terry W. Schorn,C. Gluchowski +14 more
TL;DR: In vivo, this compound effectively blocked the phenylephrine-stimulated increase in intraurethral pressure (IUP) in mongrel dogs, at doses which did not significantly affect the arterial pressure (diastolic blood pressure, DBP), with a DBP Kb/IUP Kb ratio of 16.5%.
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De novo design of a novel oxazolidinone analogue as a potent and selective α1A adrenergic receptor antagonist with high oral bioavailability
Bharat Lagu,D. Tian,Yoon T. Jeon,Chao Li,John M. Wetzel,Dhanapalan Nagarathnam,Q. Shen,Carlos Forray,R. S. L. Chang,Theodore P. Broten,Rick W. Ransom,T.-B. Chan,S. S. O'malley,Terry W. Schorn,A. D. Rodrigues,Kelem Kassahun,Douglas J. Pettibone,Roger M. Freidinger,C. Gluchowski +18 more
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A double protection strategy for the synthesis of 3,5-disubstituted dihydropyridines
TL;DR: In this article, a double protection strategy for the synthesis of dihydropyridines is described, followed by independent chemical manipulation of the C 3 -and C 5 -substituents.
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Design, Synthesis and Evaluation of Substituted Triarylnipecotic Acid Derivatives as GABA Uptake Inhibitors: Identification of a Ligand with Moderate Affinity and Selectivity for the Cloned Human GABA Transporter GAT-3.
T. G. M. Dhar,Laurence A. Borden,Sriram Tyagarajan,K. E. Smith,Theresa Branchek,R L Weinshank,C. Gluchowski +6 more
TL;DR: In this article, the authors describe the design and synthesis of a novel series of triarylnipecotic acid derivatives for evaluation as GABA uptake inhibitors, and identify 4(S) as a novel ligand with selectivity for GAT-3.
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Chapter 4. Molecular/Cell Biology of G-Protein Coupled CNS Receptors
TL;DR: The chapter discusses various roles of adenosine receptors, cannabinoid receptors, dopamine receptors, metabotropic glutamate receptors, and serotonine receptors: far more 5-HT subtypes have been identified than any other CNS receptors of the GPCR class.
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